If a emgr lecl or aotsimc lcel ahd het alrnigio atintmo,u nteh she'tre na enedarcis sirk orf carnec in trheo satrp of teh yodb tI ofo. lnyo atliner clsel ni eon yee si tuda,tme ynlo tath eno eye si at rkis rof acner.c

oiioCnhrc ilvil lnagsipm si teh itnkag of ietencg laraeimt wniiht ni het rconoichi llivi fo eth palaectn. cnoriCoih apisgnml si noed nhew a tiapten si ta high irks rof ohmcsaomolr beamilnitsoar sviueor(p p.os tsest, 3y5o ro ,ordle flamyi xh). nudirg teh -1031 sewek fo .egncnpyar

nonCfeid tapcallen icmisaosm trluess ewhn hte CSV... itsgtne mecos ackb acbk sioghwn a oi,tsrmy utb lla ntusequbse sgtiten (nda het feust sfteli) heva laomnr ohoammcsrlo un.tcso Tish amy eb edu ot rethie a rpthtsaocilbo taimontu, ro yb iiot"mrsc cues,r"e ni cwihh itmcsior sllec thta were dspupseo to eb in the ustfe aer oiecndnf to hte laptncae ot tpnreve an bomnlara te.suf

So htauoghl osriMptlsoo DSOE eniaersc smuuc dtroconipu nad is taercgovets-piotr (dan in FA deos seatt tath ti ssrcaeede cida tournopdc)i, behryte deesicnarg ssmotpmy dan nadigi in giha,nel zporemoeal si eth em"ro c"rteorc eoicch. iThs si uecasbe peealzorom is a tupnmrp-opo n,ihiibrto chihw lwil cat ylcdtier on eth poontr pupms fo het actohsm and caerdees eht ffnodineg tgean more hnat hte lspmsooitor llw.i eerT,eorfh it is the fsitr nlei rgdu orf .RDGE

So I tahe tshi sotqunei acubsee yuo nca nokw twha teh iiadgsnso si adn llits issm .it

:LD;RT ishT is lade iigisponn,o os herte is iocpisablh iilnpsgtp in a iehrpaperl boldo maers [BTU gedrin dasstisleobr olwud also be ndfuo ni the oebn arworm]

hWy iths si leda ignoso:pin (2F0A02 2)5p4

• cryticMioc aieAmn aedsu(c by dela inihnboiit fo saeteeherofrcl adn ALA d)tdhrayeeas
• vEenmtornlian epuoersx tiunaom(imn at the e,ganr eh is an )rfcofei
• GI fectsfe pmr(ayc mlodbniaa pai)n
• oNceaglrouil ceeftfs cadheh,e(a irrttiay,bili ayb,ticialrittsd fuo,etrlfg mootr swsk)eaen

Why ti si OTN hte threo anser:sw

• uAer ords - ieistcactarrch fo ctuae moeylosgnue leeakmiu iwhhc udlow etsrepn wtih npcasytniapoe (ish WBCs ear al)nmro oalgn thwi ignlrcctuai ybaetllmsos no ielrhppear ;saerm inedma aeg nteos 65 ayesr and he sah on ikrs atsfrco
• Oavl satcoyecrM - in citmcyarco menasai B(21 or oleatf e)cynif,eidc siht is cyoimicrtc sa icditadne by MVC
• Prmohleipco plseyyothcm - coruc ni rhcncoi mlcphctyiyo ieslaemuk nda nitecfuois o,nmo btho hihwc ehva fefndeirt iemlosstmogtypoo
• dRngie sstbsoraelid - rae form dael iingpsoon but aer in het beon oamrwr
• sStestoicyc - ictaicrerthasc CBR hhwci sha nbee uorhght a cgldoge eselvs nda rdeseha ,off ounfd in angmtooihirpciac ythlmieco smiaaen H(AA)sM ikle bohcortmit ooicetiphamgasinr ielk TPT dan UHS lit(yypacl myotncoric ainmae adn feftredin iptnra;tesone a niuoestq ldouw eylilk gvei ouy rmoe oinf no eht ymlthctoorbi tyahawp if yhte wdeant uoy to hecsoo tshi; ew ni'ddt even etg a etaleptl ontcu hee)r
• graTte lCsl:e onduf in bHC seeasdi lta(igumc diac ot enilys ni eolnboh,mig essauc elcrtaxuarsav )seso,lihmy ilevr si,esdea i,lpseana nda mealiaaTshs nldiso(tee ni teeihr alhap or atbe anihc of gb,nhlomaie euacss aaimne taht odwlu eb neprtse omfr dohcidhol dna luodw not hvae eonru omtssmyp)

Tihs is my tsbe eirernpttntoai with a urosce dna apraphrag omfr eth rceosu ed:tlis

nI aa,mien lohgiboemn ilbleaava is dcersaeed. Thsi sucsea edearsecd nxygeo ndbniig, nda lmytluatei esls neygox is laaabviel orf eeesarl tono ssets.ui

• O2Pa will be hrmisnalo- eacusbe the aetrilar loobd illw stlil ubialireetq in eth nuslg neve outhgh the lobniogmhe dninigb si aderdsece t(hnki of OC pinngoois ehewr Oa2P ksolo ol.ram)n
• rAelairt O2 onntcte si aatclyul dcaeserde abesuce rehte is lsse eynxog otlta libvalaea l(sse oeolhmngbi unbod ot exyg)on
• eiMdx vsnueo O2 notncet )(% si ceerdesda ofr a iarsmli seoarn and olsa fro the naeros etdils bweol
• uoVens P2O si tyghisll esaderedc acueseb trehe is grehhi xeyong aritnocxet ta sssietu edu to teh eomapytsnroc aimhcsmnes rfmo essl latot O2 genib ievdelrde dan sles 2O gebin dnuoeald isn(ec herte si ssle amnlgehobi unbdo O2 in eht fitsr place in ai)eman
• POC2 is mhsnilr-oa ofr ismarli ssorena ot het rsfti ellubt

"ehT rtroyialccu dmtstuajens ni sreeopns ot amiena ilwl eb ilaismr ot ehtso fo het rgniedpce a.sce In roedr to iaatnnmi tsiuse gnyoxe tpiusmnnooc at alneesbi lsleve tsesacdoia thwi a onlmar exnogy irrgynca pctcaaiy of lbdoo, the oircdetun ni xgeyno eeriyvld lwli dlea to na casreeni in irlacyalp pfserniu,o dan oenxyg axtritceon lliw e.inercas lrrreiatoA ndtoaiil and yoiviscts trnuoidec ofr( eth aesc of a icuteordn in t)cH lliw ecasu dolbo olfw nda ygnexo leyeirvd to ciseae.nr hBto gyxeno rxtcinaeto and xgeoyn elidyrve wlli uinotnce ot arinseec ltuni eth oegnyx setrenieurqm of eth sstesui era met or iutln the aytcpaic ot ncseeira eoxngy oeixantctr and eyedrilv has neeb a.eerdch heT nueislgrt niosiutta si eon ni hwhic vnouse xoyegn etcnont dan 2vOP aer lses tahn mranol. nSeci 2aOP si nmoalr rof lla teh ciname ioissauttn ddiceons,re thsi fceted is not essdne by eth yrarproiste eremptchr.osoec Thsu, iricasneng teh ipersdni gexoyn afnrcoit si tno ullpfeh epectx rfo eth ecsa of OC oioi,gnnsp eerwh gihh rdisenpi gyoxen ge,..( 100% nxyeog ta ebainmt iamctrboer repusesr ro ctpaenelm of teh csubtej iotn a cbiraphyer )cmahber stcomeep wiht OC niigndb at eth heme stei lal(cre dHl'aanes irfst l.)a"w - tb/N/Kwp3hshl.B/:4oonkvgswwt5nm.c.//1ib1on.i

isTh tnitape is tsnpiengre ihwt ihwt MIEST (2FA019 p)03,1 thus het ietenr elevss umst eb olcedu.cd oaCronyr spvasaosm iva a1 imtionastul e(iscanerd mosoth sulcme nantoirtcoc) oudlw ldea to sehet fndsni.gi

sA arf sa eth nroti asp,etc I hntki tshi loudc eb rerrigfne ot pt iotsyrh of isemihcc ethra ssid,eea nda eth neroisca fo aroynrco el,sta rhovwee I dton' nikht uyo doluw ende htat ot sewanr iths nsqtuioe na(d I cluod be ngoig nowd na ursynaeensc abbrit oelh of srem.i)y

tOreh hepfull gpsea rea 2A91F0 p83,2 a1 ipcetsyhmat aisutmoinlt luestsr ni esaceirdn saaclurv smtooh lemcsu taintcco.ron

sL,ta gib sup ot hte ohrerbt fro gntesti tsnemargu dsaei nad llits iagnkt ihs mrnohea ot teh crgmeyeen etpeman.tdr hPeapsr htye eewr gruiang at woh rsodpnede ot D1OV-9IC dna cidmela etnuacodi re:wso SMEUL or ro.mtiPecr

Atfre het 4+DC celsl emcbeo dfiect,en het +CD8 eslcl klli tmeh.

ibatnIyil to nniiaatm na roeeicnt = eretcile itodynfcsun. So nwo het qouensti si "yhW"?

Fiae,utg tcfluifdyi ig,epsnel cudiytlffi tanrnteicgcon is ttnrgsai to nsdou kile spsneordie. "utfyfcDiil tcoctrgn"iaenn hgitm be erdinertept as pidrmaei ueievetxc itnfcuon or teh inesbnging of rl-veaaecaulrdts edetnmai a(nedteim leardet ot llmsa ubt seumruon eaercbrl ),asticnfr tbu on Spte 1 itmednea lwil eb lbatnat .,i(.e s"lto ihs yaw oh"e,m "d,"giwnenar .)ce.t

essopeiDnr is cyulltaa oonmmc tfrae a igidlbtneati teenv eikl otk,sre as you mithg c.pexte hWti nsedespior smeco a sslo of laeuxs teitresn and heeartdist— is daedserce doibil.

nOe can aemk hte uagermtn ahtt a a"vcarslu n"ipatte mghit ahve semo ussise tihw hsi ""espip orrris,elsistoc(ea pytti/phaptsatcaimhymecarse cdfno)ytinus ,dan rfo hsti ,enasro alnucnotr rioenect soulhd eb ddareesec; ubt oent hatt onitghn si demtoneni oubta nignosgnal-td acruaslv sdeeisa n(o xh fo epesioyrnt.)hn

As a ,teursl the sbte esrnwa iocche eehr is C. io(bidL deeeasrdc tbu urltcaonn csrietoen oa).nmrl The big oienqsut I ehva s,i who het hcek eods tsih uyg wokn e'sh rdah hewn 'ehs s!ale!?pe p:

enciS hte asrte'hf ibglins is atdeffec, ew nwok that hte 'rhaefts nprseta aer bhot .rcsriear thTa nsame hte pbleossi gpyteonse of het rhtfae rea ,AA ,aA a,A or .aa

eW wnok eht eaftrh is cuefetna,df os atht neasm eh canont eb ,aa nad utsm eb ierthe A,A A,a or .Aa

cinSe herte are yoln 3 edrtieffn oypsgente he cludo evah, thiw 2 of mhte igbne rercira tnsepy,ego eerht is a /23 iblotpariyb he is a .raricre

So we inabto eth rliiapoybtb fo het haeftr spsinga no a cseevseir aellel as 2/3 tla(yibrbpoi fo bengi a rr)ierac x 21/ lb(tbopayrii of sgpasin no a receesvsi lealel if eh si a cer.rrai) The 2/3 is not envrelat ot eth rapitbiolby ttah teh hoetmr is a erc.riar

We wnok teh fycqunree fo eftfaecd dsainviidul in hte ptioauonpl ta eglar is 00/04,10 (,^)=q2 os q02=01./

P+q=,1 so 9290=/1p0 and /21))221(90(p0092=./q0

To kmea lutplicatiomni seeari ew mseaus 901,=219/0 so:

101p20020*1//2q=)=( g-&t-; hits is eth racrire fcuynqeer a...(,ak )eyrzethegstoo in eht pnpalooiut, ihchw ew anc auesms orf hte erhmto.

o,S ot easrwn eth ntiree netuiosq ew tpmlulyi hte tioyblbpari thta tehfra si a erircra )2/3( adn spesas no eht lleela )12(/ itmes eht otrbabpliiy ttha omrteh is a ieracrr 10(/)01 and saessp no hte lealel (/2;)1 pittgun ti all ethtgero ew :hvea

/*))(32)(0*//011/21()21*( = 02/021 = 010/6

:LDT;R iTsh si wingE ocmsaar baceues ti is a gnyuo boy hwit mlals bleu cell oben torum in teh dsaiiypsh of eht femur

wigEn scaarom is a mgatilnna bnoe tourm ocmonm in uoygn osyb ot;1.5.&yl pcilyyalt fdnou in teh ssphaiied dm(ed)li fo gonl oebsn u(alprtcrlyia fru)em or ilvpec lfat sebn.o tI si a amlls leub cell u,ormt nmeangi eth iedrtsrocp fo l,aslm rioufmn, mhycrrhcepotai elcls hwit ihgh :lplutcncyemusoas roai.t tI soal has na oi"onn "inks oeaslrtipe cineator ni teh neob eics(derbd sa eusist drenouudrs by ocrnieccnt elysra fo rveciate neob ni the ui.nt)qsoe oNt demnnoite si eht ioscasaniot twhi );2.(t121 [AF 0022 p 4]64

yWh teh hestor rea norwg:

• rhoaoCcdsraomn is a urotm of nimlgnaat cnroysdhcoet ag(l)eacti and fundo ialynm in eth ve,ipsl rmpoailx e,rvfe adn rsmehuu
• soicEliphion magrulano is si a aerr, negbni t-ukiormel rsoirdde cdiactazererh yb anocll ieptonlraifro of agrenashnL escll dna eht tsmo ncmmoo avirnte of aghsLranen cell Wc.ssoshyolituidoit leylik sya noethsgim tuabo kcBiebr gualrnes in the smet dna dlwuo veha icaasdseto ysmtmspo cush sa hsra [FA 0202 p44]3
• tlelpMiu ymlomea is a masapl clel iascdrays [AF 0220 1]34p htiw rotcivneoropud of c(yplityla) G.gI crCeacrtisiatsh lnceuid CARB - iher,mcplaaCey nRael nvntlie,emvo inAema, oenkc/aBB nipa deu to ehdnpuc otu cltiy enob seionls a(ycptilyl fo teh np)eis
• aersb'omolspha/WliNmt mrTou is het tsom momonc alenr ncgmainlya of laeyr hdlihocod adn esptnsre as a lankf ssam A[F 0202 p 6]06
• cromsseaOato (or nogceietso a)crmosa is a iyprarm bone umtro mmcoon ni mne .;0tl&2 It is ylcplyita donfu in eht smpsyahtei )its(p fo glno se.nob toyloiHsg woshs lrpohpecmioi itseodo crignupdo c.ells nO y-aXr uyo oldwu enpattilylo ese a doaCnm grelntia ie(laevotn fo iotr)emsupe or ursnutsb rtptean
• lSlam pmiocylhcty pylhmamo si lnaislyeset hte mase ghint as irconhc hcmoiyltcyp uekmeil.a It si odcendries a gdoniH-nnko mmphyaol fo slcBl-e nda het tmso noomcm eemaulik fo tldsau sa( ).LLC dmSgue lselc uwodl ileylk eb nees on rieehaprpl dobol remas. It dowlu ont yllike rtsnpee as na octtsoeily lesoni dan is yilunkel in ihedcn.rl 0202FA[ p]342

ME: I ntkih I llafniy heva these dsuipt aesrotg srddoseri nwdo

MBNE: Nto os ,atsf tapnerr

nyaM pdioosi kiel( hprmnioe) era enptot entishaim seerl,srae which acn sceau pitsuri dan cplnyotiahaad onstaceir u(hsc as esen ni htis iaenttp hiwt het lafica hsli,fung rdpo ni ldobo essuperr and prndgoorsceni aeirnecs ni earth e.at)r Pusirit si ytulcala a moconm esid fcfete of i.henmpro

ue:rocS stiFr Adi dna

tng7d.e:n.2o0/pwvcb/2/huit.imhs4w1n/61lbw.mp

mkNne-caPiin is a solyomsla tergsao deiessa ahtt is a eeyiifdncc in mnlehsgpinsaeyoi that edlsa ot a uulidpb fo hselpyiingmon enmNia(n pkcis ihs nseo tiwh hsi srnigeph)

pyaneeioSsghlnmi is rndoseedci a lslyaosom searyodlh

riAgnsnwe tihs steiuqon rqeeusri uoy udatdsenrn hte chisneamm fo cooteastls ltmtiouinsa by ihrtpoadayr mronoeh FA( 0202 2)3p.3

aohPdirayrt mhnooer istemlusta ltacesoosse lyientdicr yb agiltimtusn hte eeelrsa of KNARL bu sltbotessoa whcih lliw ibdn ot NAKR coertrpe on tscotoeslsa nda ustlaitme hte rsptioonre fo eobn. iTsh is a rrcaenipa cerpsos usabeec paniecrra nigilasgn erersf to untaiostiml by oihginenbrg scell rhs(to )de.casisnt

I evol ihst utqnesoi seacueb ew ear all uslvyboio deantri s.og.sdi.raoilt

In tralyie, heatrr than fgtnyieidin eyver -aryX ginve nda tyirng ot mctah it to het uqniesto mt,se eth sbte yaw to pharopca stih niquoset is ot ynfediit athw ihs somt likley i()usess dan mhatc to eht englear cicsearrhttaci of an yX-,ar igong to the -Xsray lgkioon rfo hstee iattrisaccc.srhe

eH si na clhlociao wthi ufol lsgnmeil (nidg )oeaabicrn s.pmuut Beacuse eh si na lciacoloh he si ta isrk rfo otispraani oiuampnne dna iroanceba ylnpruaom cabssesse romf niarsatopi (hiwch is why hyte eedtonimn eht btous of gklnaicb )o.tu oS awth are teh ccatiretsihscra of teshe adesisse? tnAsorapii oniamnupe is a lobar pmeainoun chhwi dwolu pensetr hitw olrab ntfitonrliia e(es ehre orf ea.elx)pm maunPyolr ecbsssa odlwu trpsene hwit ivaaonctit adn na riludfi-a nile es(e hree fro eplaxem ihtw ria iflud evlel noedtpi tuo dna eher orf /aittnsaevsbacocis nidtope .gai)an

gnnihkiT of tish won poaarhcp het syX-ra nlkigoo for picsicfe nisi.fngd nOe ash teh iar duifl lvele dan ,ttaaciiovn so thta si hte nwersa (it si na )sebscs.a enNo fo teh hrsoet evha loarb etlaitnifr and ear erihte omre udesffi or irlah os ythe oduhsl eb ruled .otu

hisT iroat si edus ot eeedmrnit iopraetaprp uopiroctnd of lugn ansracutft, so itsh byab doluw ton vhae epiapptorar otodncrpui of ucasfttran if rdbieht at eth temi fo het ioart n.ltaicocual tI luwdo go ntio aoltaenn airrrpysoet sedstris onsyrdm.e

RTL:;D nftatscura adeeesrcs nugl oecil,r os eht lack of tsfucrtana in htis aybb llwi useac an resndicae roicle hicwh iwll eeseardc eth ciunoatlnf siuldera ctcipaay FA( 2002 66p2-1)66

Suatncatfr is caerssnye to dcrseaee sfcurae tnsenoi of eloalvi and ercsaein aploicnecm of the ngusl rbe(eemrm nhew hte lgnsu vhae atgerre ncamec,piol iths esmka hte usnlg aeiser ot llfi). natatfcSru soal hepsl ot ernvpte reoaavll aeolpslc sa teh lcka of ntcusfatra osllaw herte ot be aryignv asfrecu nntsiose eebwent lrega nda lmlas lviolae Law( of cpaaLle), os ckal fo facurnatts lwuod lade to wdeiapsrde iacesaetlst (lvrealoa o)spllc.ae Buceesa ratfutnsca sevrse to dacseere seteh focsre wcihh aollrnym oafvr laopclse of het ,lgnu ti also vsrese to eaercesd the ulgn ilorec.

Lkca of tfaartcusn ni a bayb = aceenidrs veralola esacufr ,tnseoin elwro nl,mcoeapci mero alrovael apoels,lc mreo ecroil (slse aresudil lseoumv)

Totla lnug apaicyct si hacuegnnd eebasuc hwit uhonge rofec uoy acn sllit dpaexn teh usnlg ot llfu aypicac.t

arOl hrtrniadyeo peyhatr onlmocym ionsctss fo gaeuocsl/tlterery wreta buceesa of eth bitaliy to iuitezl het dmiuos luseocg eyrormts.p Where dismuo eog,s ertaw ow,ollsf so by yinhdgart ihwt shti mxeitur ti awosll fro an cistmoo "upl"l of wreat itno eht etit.inenss

eHre is na aicertl wiht rome ealdti nda a tytepr aga:dirm tlicnractisltor-.v:sriishye/-raeepokcedmgaebtsymt//hta/afiop-

nseOeoncg thwi naig of nntocufi toimtuna eald ot ecnadisre ncr,rpnsottaii etc,. eesrahw utmor srpspueors sgeen obklc ;-1-St&Gg hsaep. F1N geen dcpturo ahs RSA aGseTP ytitvaic ihwhc korsw by rntalpsyihopohg dan cgiaatitnv nortpie u(oifbinemrorn.) oS hrtee si ta lseta 1 tomur sprsroepsu eeng htat rowks rthhogu oo.shpotnirylpha

ihHg dricaca uouttp ot the onlmpryau ictraucniol rgnudi scxreeie lliw seuac hte nedossniti dna tretcnirmeu of veslosmecis nad atth woudl cueas eht aenrceis in otatl inoet-ocacsslsr .arae

reHe rae owt ismega ahtt eraiutltsl itsh elripcpin yni:cle

• liaCayplr ecuttrmerni rvuse inonaotiidsant/dettil
• rriAteoral etcnurrmtei uevssr liotddsteaiiitoantnn/

stylecelrddh-7rheooo si a mfor fo ti-npmevria 3D ehnytesisdz ni eth nisk romf BV.U It si oecrevtnd ot ilooerehcallcCf, hiwhc si eht iiatvcen morf of iVmanti D3 ttha si aaluyclt in isfrt iad.

ishT vdnauiliid ahs veacti eaiHptsit B, as needvceid by ethir apsetiiHt B farecsu inaegtn .tiipvysiot taHpiseit B rusiv ueptodrlvicy tifcesn haotcstyeep. eTh D8C lsecl liwl tsuh aacttk teh .ehtcstypeao

Ahnetro awy of rnipoahgpca shit noeustqi is ot toiecn ATS and TLA enatlveoi ear ylpiyclat iidiancevt fo yeatpctohe gaaedm.

tIo lclse aer eht aems gtihn as talleets lc,els dna rhtie riparym iocnnuft is ot toser avtniim D dan atf adn cuodpre CME hnwe .cdaeittav Keufrfp clsle rae teh i'selvr esgcam.oparh elBi tcdu iuehmpielt is not ifdeentc ni si.ehittap

hTe mset aestts ahtt het emhtor is 21 wekes i.ttegsnoa VSC is epfmdreor 1st i,trtersem ayulslu t/b 10-14 seewk asnegttoi dgriccoan to Ueat.poD-t- mAino si frodmeerp etrfa 15 weske. Fmor e-t-apDotU: mtnniicssAeeo“ hdluso eb ferrpomed arfet 15 wkese of tistoeagn usebcae ilaerer rcspeouedr era ssle lieykl to eb ecfusus,lsc ear aidoeacsts itwh hgeirh aestr of lecl ctruleu erlfiua, adn yrrac aeregrt lfeat k.s”ris

hWne a mcselu nrsu tou fo lufe ,e(g locu)gse o/darn cpgruoidn essl PTA adn deicsn”era“ uuoilmantcac of setmlaetboi la(l teohr sonpito essbied eth rceoctr oc)i,hce ti si a insg fo ntseo fo lmcsue .tgfaeui eTh tmse si gsakin wchih of the illfonwgo wlli sadere”,“c?e nad it is the Hp htat illw aeerceds si(oda)isc eud to het iamuactculno fo actlic caid be(rmreem icyossylgl htpwyaa ehwre yeuavtrp egts ocreventd to cilcat )adic.

sThi tepiatn setnreps hitw lsiccsa rupep rotmo ournen leonsi s:mopmsty akw,nsees elfxreehr,yipa dna ecarededs etaonin.ss eHov,wer eth qtnosiue satest hes ncaont" ellt ehtewrh reh eftl atrge teo is aidres or eerp"dsesd hnew erh eesy are csleod, hciwh aym akem oyu edsronecri nda thnik hetre amy be eoms etpivopiopecrr ssuise yhte rae ngtiry ot nthi .ta ishT is ont hte .caes asieylEcpl eocn heyt ienontm rhtee ear on eotrh boiemainltras e,.i.( no purep ilbm rsbetnaalmioi or rtigh ddsei .ilotminb)eaasr If isth is teh ac,es rhtee si no dagmae to eth atcsrt at lal cihwh( aer sllit eidcsdnreo U)M.N

feTereho,r het eadagm is uerlpy toorm nad snoryse ni hte eftl g,le hihcw si on eth deimla teacps fo hte arlntfo and iatlpera lobse c.riltsypeeve Tihs aare si ipduselp yb the treranio eclbrera ryter.a

This si thaw is knwon sa a atcsmoi mtauotni: a niotumta atth ccrous in -innneemrlog sllce ,nda fehro,reet oyln eftfsec utgreadh ellsc deeivdr fomr eht ptaenr ecll with teh maoit.tun S,o a uiomntat reuroccd ni a etefaitdfenrdi preant clle taht agev reis to a ste fo edaturgh esllc hiw(,ch in htis ca,se weer eteddins ot ecoemb etanril )us.esti

ofunidgoCnn" re"bialavs eehr amsne dgfuinocn"no sai,"b niesa.llsyet And shit is rtue uebceas a eotivecpsrp oochtr klsoo ta a ecicfpis xpeourse ot a cssunebta voenita(rnmnle nox,it gr,ud ,ct.e) nad assk "Who will leevdop sith edsesia if pxoe"eds? SP'sC loko mtattpe to nifd a ritaleev ikrs eotdascasi whti an eeox.purs eTyh do ont ktae toni nuctoac het ftfaces trohe sxoupeer.s ishT is your ofgnuoncidn sb.ia AF gesvi het mexpale of cnnfdoigoun siab sa roamP"nuly eedsais is mreo ocmonm ni wkrerso ni a loac mei;n v,hroewe emsinr era more llykie to ,k"oems dan isecn ikmsgon nca also laed ot lamrounpy sie,dsae uoy n'cta yealrl ays eherwth eht knisomg sfri(t or coesnd dh)an ro het ocal utds ssauec hte opbe.mlr A iiccnall l,tair no eth ohrte ndh,a cnitnoas a tets rpugo and a ootlcnr u,orpg os iarebsavl shuc as eht odinougfnnc aevrblia emetidnon veoba are mel.diti

LRT;D: uoY atnw teh msot visnetsie stet tsfri to uerl uot eht eaediss ni asgieevtn a(lset hlokeloiid fo flaes iatevnge) dna hte osmt icipcefs stte tnex to "reul "in lyon ture eitspovis stela( dioioeklhl of lesfa pi)voisste 0[FA022 725p]

heT wya I wsayla htnki of tisynetiisv nad pcsiiicyeft si ni oeialtrn ot alsef seieagvnt and safel itisso.pev

• hHgi Se N ysiietvt nsame ouy rea ssel elilyk ot vahe lsaef igatesevN seoo(men who sah eth edissea btu estts ateeni)gv
• igHh s P ycfecitiie nmsea ouy rae sesl lekyli ot vhae lasfe tiPiosvse oe(msnoe how estts spvteoii ubt osde ont ahev teh sdeias)e

In sith seqntoi,u ouy anwt ot eseunr oyu era only tirnaegt ohste hwo cayatllu evah the saedes,i ro in oerht odrsw that you atnw ot imznimei oyru easlf ptovssiie. ehT etsb wya ot do sith is ziemixam ciPtiefiyc.s teTs 1 sha %010 icspyietfci ienagmn ti lwli ahev ysasneietll NO flaes vpitoeiss iwchh si taerg os we eiftinydel nawt ot sue it imieiang(nlt lla tbu two !tsp)nooi ehT trbtee wya ot nreesu uoy rea cinagtch as amny sasec as lsebsipo hlwei tlsli ynlo itgtgen etur vietspios is ot sett hitw ttes 3 irtsf, hchiw ahs a much ighhre t.nytiesivsi Taht awy we rea unilrg tuo easedis ni eht eaisvetng of test 3. shTi alos adds ot oru ailtiyb to only trlyu etatr oesht iwht deseias sa we veha rueld uto sedsaie in our ftisr etnaigev oloitnp,pua tneh ew etts het episvosit to ru"le "in deieass iwth a hyhgil cepcsfii ts.te

Teh usise wthi ungis steT 1 fitsr nad olny sitgnet eht evossitpi is we okwn teh pvisisoet ormf stet 1 are ylilke reut stesi,ipvo as het hgihyl epscific tets wlodu veah a siyabclla zroe fales vsptoiei rt.ea tA htat ption rteeh lwdou be no tnpio ni egnstit thwi test ,3 as we aveh csyialabl a eutr pioivtes plaoo.iutnp The usies si ew eahv imesds a lto of ediassed ude to teh lwo itetsvniyis adn high lseaf tiaegvne erat of test .1

hternAo ayw ot ihtnk of htsi is to mremrbee hte omlsrufa s(a estiyNiivts nocintas selaf es,gavieNt dna cyiPicsetif ctonisan lafes sioisPvte ni teh sra;mulof see :)dsAirtFi

• tiveytsnisi = urte viespoit / uer(t tipovise + fesla ieg)vtaen = 1 - lafes itgenvae raet &-gt;- gihehr niyitessivt naesm elss erta of aself evigtnaes
• pyiefcsctii = etur itvgeean / rtu(e egainvet + afels ps)eitvoi = 1 - sflea soietivp tare -tg-;& hgireh isyipcticfe manes sesl tare of sefla optissive

O/SNPUNITS laso eshpl ot remerbme htat efsipcci ssett rule in eidseas, adn svesnitei sestt erul uot asdeesi

tonrAhe tNRA ahs to ahtcat to eth A iset eforeb hte ptepdie inhca can be zohdydreyl fmro eht P esti and eodvm to teh A etis RtAN AF( 0202 pg )54

eth rmlalakh fo miaogenmni is sti reaonitl ot a gminenela cusarfe nehec rtoalnie to sscluu

nn/a-m9u-wklmhgn0i.2oate/neml2:-2thatsocotbs0ibl9bet-.pmh-/st/caeswlotlpsm./1roxe-p1

Thsi eintatp ihwt a hoyrtis hrnoicc rsneyonitphe si tsom klyeli snigfruef orfm tlfe rahte rafeiul r(ddaeesce icaardc op)o,tuut nsgiacu het obdol ot cakb up in the ngsul eC(lrkcas aer edarh llliaytar,eb rnsosehts of hat)bre nda htat rtgnelisu tnoi eicasnrde lrteaadfo rof eht ritgh seid of eht r,aeht nigrsia hte sreseurp in the trhgi arthe ,haresmcb hhicw gte rttiedmsant kbca to aenlrct eniv.

eTh above si ccoterr ni rsetm fo ,oAM ohevrew I eevelbi eht tsem etssta it is TP mb(inrrpo)oth oognrp,aiontl not TTP ralt(Pai bslmrti)po.haTon I ddi ton veha nya daei twha oilmurcda s.w.a tbu hree aws my log:ci

1. ttinePa dah otacri valve n,tmlaeeeprc es'sh 0,8 lpbboayr utp on an icluaongant-at
2. I wonk niarfWar si dols ruedn eth abrdn anem oaiCnudm
3. Rdmine esyofurl ttha nrWafi aws orescveddi ni 9721 (2,9)7,01, nda tibniihs Vti K edntneepd tiltcgon scaortf it(v K idncylfcik-eeei tt)esa
4. unocnePor het dgur ton ni FA sa rodOUCM,ial dna you slhla lefhylpou now wkno it sola siibthin oedpixe daetsucr,e nda eduosp geuss oyru awy ot cotr.iyv

sTih Q doluc eb radwsnee owt ,sywa one goruhht oiniimaletn or owgnnki how to ienifdyt het uc!el owN via ilomiinaent ..A ). iaynml eens in SDIA tpansite ( Q tmse sedo not idtcer Q hatt C)a w)y louF melgsiln eirrhaad "yt)tD f"a eTreh sdeen ot eb a ardit " yse lHPgEATymaeO + eolmneygl"apSe in"skpig e"fevr cyn"nipt"aapeo yma sloa veha ksni etnvvmienlo )E ulfo nlgmseil ergne gnliava ardechgis

B) CEL*U RUQ NIPA + culer

isTh is tyeiaselsln a ormafl ocilg outse.nqi icLolyalg ekn,sigap eth nstoique sska us ot iinydeft a semchamin taht mtoru pessoprrssu vhea hcwhi enp-coseonrotgo od o.nt In oreht rs,dwo thaw si a ihmsceman sedrah by lla nowkn otmru opsrsusespr utb not rshdae yb any kwnno opcotsrn?eeoong- orF tath n,ersoa it nc’at be nhlhopoarsyp;toi eus,r yopitalrspoohnh si a mmseicnha fo utomr rppesorusss utb ’its olas a ienhacmsm of mnya nkown opeenoogcn.s-rto

;RTLD: lnaeR lcle rimnacaoc cna erptnse hiwt ylcomyaehitp (eud ot desecrnia ritopyrt)ehenoi and pcchiamelraye (edu ot rHT)PP FA202[0 28p2]

oS het eiosutqn is waht si teh iarymrp ?nrecca He sha wot moutr olointcsa en(diky nad gun,sl) which docul be mrpirya ro rofm stata.smsee

I aoedrnrw ti wndo to ttsaamicte arenl ecll omacnrcia dna bngchoceroin qsuomasu lcle ciroanmca se(e b.)lowe ehT onyl eohtr ioametnniof eayllr eginv atth coudl laolw us to iiutdssighn si eht lba uelasv ndcnaiigit taenlapaiprcso rymssdnoe. eseTh rea othb nnowk ot ausec plceporiaantsa yessndomr hhicw nac eaucs cica.lmpheyrea oS sfcnuigo no the eyymioh,captl sith si reom ispcfeic for elnra lelc raamcncio aubeecs no glnu accren secserte .EOP

I teeiimland enteetidffiuanrd anciamorc ucbesea ti si too ifocsnipnec nad tciaeasmtt oninltarisat elcl cncmaaoir ueseacb it is arre ni eht kindye (wthi no laiasoepntpacr nsemyodr atpllyyci aseitadsco ihcwh ludoc aescu teh bla atlienima)obsr dan ereht si on eimntno fo bra.ledd

lMultiep oaemmyl cna ehva rnale iveotevnnlm tub eods tno atcillypy nvoevli eth ulsng nda uwold npesrte ihtw nbeo tlicy ssiolne adn aaneim arreth anth aihtyyl.eocpm 0A2F[20 314]p

eTh key ot rwinsagne itsh is tath hes sseem crecnndnoue with reh mstpy,mos chwih si a lmaalhrk fo csrivoeonn doedisrr al( lebel )defnfcirenie [F2002A gp 5]66

llensIs yeatnxi drordsei wdulo eb tcpoeunpcaoir iwth avignh a nriteac eslnils, dna nyiiilabt to eb ersserdau nhew rheet rae etienvga indnfsi.g

enlsdioaotale/Draezeprnanizoiit si a adoistcsviie dirersod and "out of yobd eecxerpe"ni htwi a eenglfi fo ahdnecttme romf teh yodb or norvitenn.me

Bfrei thcpiycos srdidoer uwlod reesntp orme ikylel tihw ls,ienodus ,couinilathnals or osme ertoh achrcisctratie fo ihcysposs.

TSPD luowd neetprs ftear an yexmleter artitcmau neevt nehw tmpsysom hcus as an,xyiet blcfssahak, esuoaapy,hlrr dna rnishatemg iprtses fro gareert anht 1 nohmt afret hte ent.ve

As the elmcsu rksow nad asebkr dnow ,ATP endisenoa is ucpeddor, gnleaid to na cenresia in het isuset.s Thsi iesraecnd aenesoind sscuae itvoa,loadsni ichhw ni turn acsernies saaluvcr tnceacnoduc eth( fwol fo a uloevm of odlob hutorgh eht .ceu)ulrstaav

ghtuloAh uyo mya kthni smluec norcnioctta mya deal to a edaresce in wlfo ohgrtuh teh (evlssse) yb useqnzgei wnod no t,mhe itsh aemnmchis si rmovoeec by eht cesdnriea dcaairc utpotu rfmo teh .rateh

vyScur si hte inyeiccefd ni iitnaVm C. nViamit C is ycseasern orf dnioyxthalroy fo eoiplnr nad iynsel sesrediu in gnaloelc. lolyPr herloyyaxds is bsepinloers ofr teh dhynlaxytioor of pelnroi e(es tshi Wieiapked ciartle)

rcPeeesn of clluettneamdui tanig eslcl rngnsduruoi irognef dboy ls)tap(e shosw lnaamur.og

ishT rereuisq ewldongke fo OAM for tiesasseoorphdphe iniiohstbr ichwh( rae soal sdeu rof ecteelir dtn.ni)usfcoy llA ehaoieprdpsohtses rthiioibsn illw itibhin shorsepoat,spdeihe ihcwh ayolnlrm eayasclzt ysyilrodhs of MPAc or GP,cM so eyht wlil kwor yb nicnargsei MPPGMccA/ !eleslv 2[A20F0 2p64]

OT:NE do ton teg fcnuesod yb teh ndiodati of ON sa na rsneaw, hhoutg aoierltre nltodaii by hrpoehssdatoesiep sinrtihbio oswrk in arpt yb hieacgnnn NO iivyctta on hsotmo cmle,us it osde tno iasecnre eht ntntaceionocr fo O.N ON irrggtse arcndiese cGPM ot eailtd msohto emssclu, nda opesesrsidhotpeah hniobitrsi tvnrpee wneakodrb of hits ,MPcG os eyht kwor in yernys!g

Teh tgirh yee's feeternf vresne era ow,nkrgi as etfl eey atltuimniso ussaec a hcgnea ni the ghirt .ey eeTh hirgt eye opitc n. adgema sasuce tsi' tnfarfee n. ot eb a.gemdad It 'tanc cryra ionf to ir,nab os thgir nad tefl yee 'ctna ntsrotcic ot htlig.

h38pi5mbwod59.ml//vw/..2/tt2euhpwnn5ni:c.bsg

liWeh not iiltydorntala sesud,dics eth eiskd'ny rstonibucotin to niingaaimtn lecogus maoothsssei era afgsticniin adn cineudl such nnuscofti as lsraeee fo usclego inot het oailcuctinr vai soocgleeugsi,nne ueaptk of olusecg fmro het urncatcoiil ot ifatsys rhtie yegnre ede,sn nad iptasneorbor fo cueglos at het ellev fo teh oxpilarm blutue.

021A9F 8p7 - e[ucolsno]ingesG oucscr iramryilp in teh ;ierlv esrsve ot tmaaniin eluiaegmcy nirgud as.fitng zsyEnme lsao dfuno ni iekdyn, aeintilsnt mlpieeu.tih

... smees eikl a islly tngih ot .t.se.t hrugss sseuhdlro haglsu in NBME

mocAntii ulidf plidsphohoip salinysa si ueds rfo tnegits telaf nlug ruiymtat iav uirsamneg tucasfnrta coidonpur.t

eFalt eygpicraodcraohh owldu lvraee any lncnieatog hrtea tecesdf fi ste,pern btu oldwu tno eb dasigconti of nwsoD ydeornsm

Fltae dutalruosn esitir-srrtFtme aurnlduots lmoncymo sowhs eeascrdni anhucl naurcsltency and lcistyophap anasl nobe. utB I efel itsh is euds mroe mmonylco ni derol oemwn how mghit veah ohsclrmomoa eesnsgdyis sa eth aucse fo dowsn mdnreoys

ealFt iyopbs Pyrtet vanvisei neiu,hetcq enwh ew ahve a sserle vnviaies nda omer ccipfies sett ebala.vail

FA 6gp14

thgit sjitncuon etnewbe tjendaac lstioer celsl fomr debtsotl-sio rar-r&g-;tibe iotsael amegste fmro outemnumia sckatat

shiT si D6GP iec.edyfnic F220(A0 p242)

GD6P ienyccefdi acuses a ymlhcotei eamnia hnew viidsiaudln ear xesdope to rlianaatasilm eud ot hte adrceseni tvaiixdeo sste.sr hisT si ude to hte efndeciciy in lrhiginpnese HANDP wichh is seeyncras to ihipesnlr edrcdue ntitulhegao hhwci dias ni ehignncqu erfe .scidlaar

ehT tisfr hntgi to loko at is soim,spuat chihw loudw ecesaedr ueescab ninilsu fitaiceatls rriunleltclaa itfhs of umipsasot hi(hcw is ywh it si ueds as a atnremtte fro ehikmyla!ear).p isTh alvsee nlyo owt taptlneoi rwessa!n

The xnte hnitg I ltyimmeaied dineoct aws taht uro asep'itnt albs einadcitd nonia apg ioatmcble asdiiosc ly(leik deu to ibcdiaet oi)esokis.atdc imtrsniAadonti of nlsiniu odwul orevpmi stih oncinot,di and eon of het ianm intgsh tath odluw cruoc is irtocceonr fo c,aosdiis so pH wodul .esarcnei Teh hoter rtpas fo the nswrea alos amek n,esse as aerbnbiacto bnegsi to ertnru to mranlo htiw eth aeesricn in Hp dna lsse isetcynse orf ues ni nubfif,erg UNB eassderce as teh diykne geadma ocrrucnig nca be tlyosm rer,edevs dan obldo 2CO eensrasic ebascue ehert is on nlgero teh ened ofr oeriaytsrrp ocnenpimtaos fo teh iotebclma ciaios.sd

aWter dsoe ton ruqreie nraottprs eprinots or eyrneg rof soita,nrpob and lantsepehrtaiil notprarts masne ti tusm go ugohthr hte etpaleiihl scll.e C is eth tesb ca.htm

:TDLR; lcTe-ls rea iyirlprma perbseinsol for hotb euact (wseke to n)tohsm nad ochicnr to(shnm ot syer)a jr;coeinet htis odluw eb taecu necjtoire 2[A002F p1]19

ctpaurHeey enoiejtrc us)tnemi(: from e-pmfdreor iaentoidsb in hte ripteniec wichh rgirgte an imnume esnperso ni het crepienti iva tecpmolenm antiaocivt epT(y II riiti)yvtenspesyh

ctAeu jnRieotec skewe( ot noths)m: eicrtinpe elcT-sl ineecrgoz doonr MCH on oondr edridtinc sclle pyT(e IV eetipv)nyysitisr;h aluohrm oemncpont epTy( II vtstyieei)hprnsyi to a eesrsl nexett EARFT teh cTse-ll avhe gidezocner teh MCH as ronfegi

hnciCor (ntoshm to yser)a: ectrnitpei llTcse- zierocneg esgnaailltno hiwch[ era atinsneg chwih udowl be slfe in a romlna eussti ni the noro,d btu rea zoerendgci sa nrefgio in eht netecrp]ii esretpned by epnirteci idndicrte lecsl ye(Tp IV n)eyytetsish;rviip horauml nneotcmop pTey( II vnsh)retsiyteypii ATERF eth -llcTes heva giceonrez the HCM as negofir