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NBME 19 Answers

nbme19/Block 3/Question#49 (reveal difficulty score)
Schematic representation of eukaryotic translation
Binding of aminoacyl-tRNA to the A site 🔍 / 📺 / 🌳

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submitted by strugglebus(177),
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KO, os fi I ebmmerre yorcertlc iths is teh oen atht shows teh nicarthenie t.nrpaet rmocadniotilh is lsoa sepads yb het ret;ohm erhvweo, ti anc evah reaaivlb eysxptivseir adn iecopetlmn n,taerepcne hhwci is hyw mose mmserbe were otn fteeafc.d

submitted by wherearetheanswers(14),
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Aetnrho tNRA ash ot tthaca to het A tsie oebref the itpeped chain nac be lreyhzdody ofrm het P seit dan edomv ot hte A teis tNAR A(F 2020 pg )45

fataldose  As the Peptide chain is transfered to the tRNA at the A site, the ribosome moves down the mRNA moving the now empty P site tRNA to the E site, and the tRNA from the A site to the P site, making room for the next amino acid charged tRNA to attach to the A site. Additional points- The translation comes to an end when a releasing factor recognizes one of the stop codons (does not code for an amino acid), which then catalyzes the release of the peptide chain from the tRNA in the P site. Peptidyl transfer to E site is wrong because peptidyl tranfer occurs between P site to the A site, not to the E site eIF4E is a eukaryotic translation initiation factor involved in directing ribosomes to the cap structure of mRNAs. Once methionine charged tRNA locates the start codon, all initiation factors are released. +7  

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