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Retired NBME 21 Answers

nbme21/Block 1/Question#48 (reveal difficulty score)
A 44-year-old man is admitted to the hospital ...
Increasing cGMP ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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 +9  upvote downvote
submitted by โˆ—divya(75)
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eecarisn ni PAcM G)s( - 2beta - aasotilonivd

deaersec in PcMA )i(G - lah2pa - torinaoctscnvsoi

aseernic ni PI3 GDA G(q) - 1lahap - ntaocsvinsoroict

inrasece ni PGcM - 3M - NO ddeincu nailodsvatio

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cytotoxict  Alhap 2 onisgsta od otn ecuas csniocoiattrvons /cb hyet lead ot evnaegti becadekf of eorinp dna tuhs deearecs asctymipteh ensesopr +1
payingforthisisdumb  FA02 73p1 siag2ntฮฑo-s nerseica Mc/ONGP dan ivoledasat +
sarahs  ywh is rgnecsadie McAP r?owgn +1
hiroshimi  :arsh@sa you wnat to erecaisn McPA ceaesub it dowul dlae ot anstvidloioa dna eplh to rceaedse sih odolb seuser.pr esiDnraecg PMAc ldowu aekm his PB wesr.o +
fatboyslim  2laahp oltsuainmti ssauec nltdioivosaa esabuec ti si .ymhstpyotical +

simple rule of thumb is

Calcium --> vasoconstriction (smooth muscle constriction) -- > must be Gq (alpha 1, v1)

rise in cAMP and cGMP both vasodilation (cAMP by inhibiting MLCK, cGMP by activating MLCP) so whoever causes vasodialation must increase either. cGMP is niche (NO, ANP) so most of the time it is rise in cAMP --> must be Gs (beta 2)

only exception is M3 it rises calcium (Gq) but in endothelial cells , not vascular smooth m. cells, so NO produced and causes vasodialation via rise in cGMP (again!)


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 +2  upvote downvote
submitted by โˆ—vi_capsule(21)
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HNT egcye,remn Sudmio osisdNrt.iurep nlUiek ndahlzriaey a ecnbdala arioltvdsoa iv(en = iea)rrtol

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sympathetikey  Well etnh, I essug we dusolh sjtu fgtoer toaub uor dol pals het hA-a2pl nodtoi.ga Goss al.cl I n'iddt enev ees ahtt iths saw pnhriyseevte mgencerey. umbD no ym p.rta +
zup  so aey enndcioli wlduo eb esdu for ivepetserhyn cgeur,ny btu htis guy is orev 081 210)( os eyth haev to ues gtmieohsn klei yzdarinlhea or ntdersrioipsu btoh will eincraes MGcP +
whoissaad  uDrsg deus to ertat TNH ea eeads rppieee:sNrcmllnycte nodoia odFlilCri iaoddeLlneibpgomvniipCrNnietnu +18
lola915  lrniaHeadyz ylaaclut talsaesvdio etvrei&t;isnsegar dna psotdsrrieNiu aotdsviesla artsriee = nvies. thoB seeinrac PMcG. +12
vi_capsule  SO tihs tsei sego aetfr meyno !own at stael my tmomencs e'tarn rbcdslema lol +2


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