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Retired NBME 21 Answers

nbme21/Block 1/Question#48 (reveal difficulty score)
A 44-year-old man is admitted to the hospital ...
Increasing cGMP ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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 +9  upvote downvote
submitted by โˆ—divya(75)
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esceanir ni McPA (G)s - e2bat - alaoitsidonv

aeredces in MPcA iG() - hpala2 - ninoatcvtrissooc

nseeiarc in P3I DAG q()G - lap1ha - ocvcrissnitoonat

encsriea in McPG - 3M - ON udndcie taaliosdniov

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cytotoxict  lapAh 2 insagsot od not acesu ivcnnoatcsoorsit /bc eyth adel ot tegeivna bekadecf fo eironp nda hust esearced cpimahystet ensrpseo +1
payingforthisisdumb  2FA0 73p1 tioฮฑ2gnass- ecniaers G/cPOMN nda adlaoevist +
sarahs  ywh si caregesdni PMAc ngr?wo +1
hiroshimi  assrah@: you watn ot raineecs MPAc asueebc ti ulowd dela to vaaitsoodnli nda lhpe to csadeere his dobol u.rsrepes eeaigcsnrD cAMP dwolu amke hsi PB reows. +
fatboyslim  aphal2 loaimsttiun sscuea niaoitsvldoa eaucebs ti si aoptstlciy.hym +

simple rule of thumb is

Calcium --> vasoconstriction (smooth muscle constriction) -- > must be Gq (alpha 1, v1)

rise in cAMP and cGMP both vasodilation (cAMP by inhibiting MLCK, cGMP by activating MLCP) so whoever causes vasodialation must increase either. cGMP is niche (NO, ANP) so most of the time it is rise in cAMP --> must be Gs (beta 2)

only exception is M3 it rises calcium (Gq) but in endothelial cells , not vascular smooth m. cells, so NO produced and causes vasodialation via rise in cGMP (again!)


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 +2  upvote downvote
submitted by โˆ—vi_capsule(21)
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NHT e,ymerncge uSmdio .dNpesuorrtisi liUekn zeirhndaayl a cealandb lsiavotrdoa nei(v = lrtreoa)i

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sympathetikey  Wlel etn,h I sgues ew odlshu tujs ftrego tuoab our old salp hte -2lphaA asonoosGi.g dt l.cla I dtnd'i evne ees ttah siht saw tsenyperhiev nyceregem. buDm no ym trpa. +
zup  os eya nindcoeli wluod be ueds ofr istneehepyvr ,uercgyn tbu sith ygu is oevr 180 01)2( os etyh aehv to ues onehmgits leki ynhzidelara ro isepirutdnosr hobt wlli sreciane cGMP +
whoissaad  Dgsru sdue ot atrte NTH sld Npednaepoioi tieeidrnLtm lonyd FCveraeiCNlioimel scpdlgbpieinnrnuaerceao: +18
lola915  Hdyeianrazl uylacatl vleodsaitas ietanivsgst&re;re nda rssedNiitupro atoladsesvi seiraret = .evnis ohBt reacsnie PGM.c +12
vi_capsule  OS ihst eist geos afret enyom w!no ta eastl my csmnoemt aet'rn albmdserc llo +2


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