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Retired NBME 21 Answers

nbme21/Block 1/Question#48 (reveal difficulty score)
A 44-year-old man is admitted to the hospital ...
Increasing cGMP ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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 +9  upvote downvote
submitted by โˆ—divya(75)
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neacsier ni AMPc s()G - tba2e - ivnoilotasad

esedaerc in AMcP (G)i - 2hapla - ooisnntrvtsccoia

nsreaiec ni 3IP GAD G()q - h1lapa - tcasootiocvinsnr

neseacri in McPG - 3M - NO ucdnedi stiioadolavn

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cytotoxict  ahlpA 2 itssonag od ton ceasu instoasonicrcvot cb/ ythe lade to tiangeev aeeckbfd fo rnpoie and hsut ceeresda stpcyemtiha osresenp +1
payingforthisisdumb  A20F p731 -snsoaฮฑi2tg naisecer M/cGNOP dan aeiodavlst +
sarahs  hyw si eedascirgn cPMA orgn?w +1
hiroshimi  ssar@ha: ouy awnt to eranscei MAcP ecubase it dlowu dlae ot vloaatdiosni nda ehpl ot reeedsac shi ldobo prreessu. sDiencgrea PMAc louwd akem sih BP ro.wse +
fatboyslim  2haalp otntluamiis usasec niovlaosadit cbuseea ti is ayymlo.ipctsth +

simple rule of thumb is

Calcium --> vasoconstriction (smooth muscle constriction) -- > must be Gq (alpha 1, v1)

rise in cAMP and cGMP both vasodilation (cAMP by inhibiting MLCK, cGMP by activating MLCP) so whoever causes vasodialation must increase either. cGMP is niche (NO, ANP) so most of the time it is rise in cAMP --> must be Gs (beta 2)

only exception is M3 it rises calcium (Gq) but in endothelial cells , not vascular smooth m. cells, so NO produced and causes vasodialation via rise in cGMP (again!)


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 +2  upvote downvote
submitted by โˆ—vi_capsule(21)
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HTN n,gmereyec oiSudm rtre.iNspidosu kUleni nerailyhdza a cdaebnal daolosaivrt eni(v = oir)rlate

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sympathetikey  Wlle ,hnte I usseg ew hldosu ujst ergtof buato uor lod pasl the 2haA-lp n sGti.oagdsoo lal.c I dt'ind enve ees htat sthi wsa rhviteesyepn ecrm.yeeng mDub no ym rpt.a +
zup  so eay innolidec lowdu eb esdu ofr rsnehevtyiep uner,ygc ubt iths gyu is ovre 801 (21)0 so teyh ahev ot ues iohgmtsne ilke yhanaerzldi or redursstoipin obth wlli reaseicn MPcG +
whoissaad  ursDg duse ot ratte HTN ineoNeniv leC yCge:cmFeLce omdprnN iironlersadrila piddtbiipol nltoeuapaisdene +18
lola915  ilradnzeyHa lcauatyl alvdsaitseo nsgt&ev;reeatsiir nda dtupsseNiorir olsdaasitve trraseie = vns.ei tohB resncaie GMP.c +12
vi_capsule  OS stih stei eosg tefra neoym w!on ta ltaes ym nmcomste 'ertna drsblmeac lol +2


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