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NBME 21 Answers

nbme21/Block 3/Question#49 (reveal difficulty score)
The gene that codes for a protein normally ...
Deletion of a hydrophobic amino acid sequence from the N terminus 🔍 / 📺 / 🌳
tags: cell_bio cell_trafficking cell_transport 

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 +63 
submitted by pppro(25),
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siYrneai tehvsir ni ldoc eearprmsutte nad acn be ioebantd rmfo orpo tnaieadst .kmli kh(eCc htekysc khtcse)


 +54 
submitted by drdoom(1045),
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Teh setsnyshi fo vuialytlr lla isretopn t-ip&pmNA()Rgdte;e usocrc in teh apcy.lmtso1[] h’tasT herew lla osimrobse ,sredei freta all. mbois,esoR whcih aer tlosym jstu ANrR /3~2( ArRN + /13 i*rpt,noe by )whitg,e rae esledsamb in eht cnsuule ubt onyl od rhtei fstuf eonc teyh tge ot teh .ostymlcap

orF a inperto ot aveel tis inoilrga tnhmoweo of eht ctoosyl nad beeocm a tierdens fo eht uencsul or, syyyy,yay teh pomsnelicad uru,meitlc ti edesn to avhe a ttllei rnsitg of miaon iasdc ichhw uosht “I lenobg ni hte uncl”!esu or I“ obglen in the ondpmsaielc lc!umtruei”

eitProns iemutltlay sndiedet rof the ER ntiocan na letaaiinvgiymun mneda trngsi fo naoim dacsi kwnno as ng“lsia eqc”e,nsue ih,hcw for eht srsoepup of teh etpS ,1 is ayswal at teh Ntni-rsu.me The agsnil eceenuqs lsetl roteh sicooclyt irptso,en “H!ye aTke em dan( eth tesr fo hte eepptdi of ciwhh I ma patr) ot the RE!”

In het ebsacne fo iths ialsn,g a tiponer ilwl einram in tis e”dufl“at mhoe of het otocy.sl

s;uHo&rseqer a icne mciaehcts shiognw teh ofwl fo itnepros ormf aiilint snstieshy to flani si:ieostatnnd


Enstdoen

  1. ehT“ nhsysstie of raylvluti lla nosertpi ni eht cell inesbg no osbersimo ni hte ”.lsytoco (tnsaEseil eCll Boigyol, srbltAe et ,la. 401,2 .p 42)9

I*f uoy lrlaey tnwa uyor dinm nwlo,b oincsrde tath even the rioptne uutsbsin hatt mkae up ttha 31/ fo a meosbior era hvmesetels nliyiialt yhetndiessz in the olc;tsyo lrea,t etyh rea rnretpoatds abkc inot het ecluuns via the nrclaue pro.e

qball  Awesome explanation. Now explain it to me like I'm 5. +8  
drdoom  All baby peptides are born in the cytosol. But some baby peptides have a birthmark at their N-terminus. The birthmark tells a special mailman that this baby needs to be delivered somewhere else. If you chop off the birthmark — or erase it somehow — the mailman never knows to take baby to its true home. The end. Now go to sleep or Santa won’t bring your presents. +60  



 +11 
submitted by jejunumjedi(30),
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I tkhni shit si igisrcdneb a ansigl iedetpp ooychdbrihp( ta usnmtir)N.-e thtuoWi slaign pedipte g=&;t nact’ eb oradstptern noit cpdieaslmon um.eitucrl

youssefa  Is this even in FA? Biochem chapter only mentions SRPs. +1  
lovebug  @youssefa FA19, pg 47.[cell trafficking] but not details... +1  



 +2 
submitted by baengotti(2),
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Teh eitusm-nrN si rewhe yuo have aislng eesppitd iwhhc denfei the tratge of eth enoprsit in(tkh of thme as lpstao eoc)d. palcyy,iTl itnreops era in eth mclpoayts rtfae eyht ear a,edm tub cisne het ehva gtas ta nsun-t,mrie eyth go to rfiftdeen gtersat elik this esac .RE ,wNo fi hte nrteoip si eertanid ni het oysm,paltc hist emsan het ttoanmui idlaesbd the agt no( tasopl coe.d) ecnHe, ti si epkt in eth opltm.csay

minion7  jus a reminder........ I cell disease - mannose residues are to be tagged by phosphate to enter lysosomes - failure of phosphorylation in golgi due to absence of phosphotransferase - proteins are secreted extracellularly but not to lysosomes therefore any protein formed will b tagged before it enters any specific organalle!!! +4  
michsmith49  N-Terminus assists with Navigation. N = Navigation. +  



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