NBME 21 IgG plus complement (NBME Answers)

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NBME 21 Answers

nbme21/Block 4/Question#24 (reveal difficulty score)
A 56-year-old man undergoes a renal ...
IgG plus complement 🔍 / 📺 / 🌳 / 📖
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submitted by ∗h0odtime(54)

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Transplant Rejections (p.119)

Hyperacute - Minutes pre-existing Ab attack new organ Ag + activate complement T2
Acute - Weeks CD8 +/- CD4 bind organ MHC. T4
Chronic - Months/years CD4s can activate macrophages and mediate damage T4, or activate B cells --> Ab --> damage graft. T2 or T4
GVH - Time varies, organ with T-cells grow and reject foreign host. T4

Transplant Types

Autologous Self skin grafts
Allogenic Normal organ transplant
syngeneic graft (isograft) Monozygotic twins
xenograft animal to human heart valves

ABCD Hypersensitivity (p.112 FA2020)

T1 : Anaphylactic & Atopic
T2: (anti)Body-mediated
T3: Complex (Immune)
T4: Delayed Cell Mediated

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+4 upvote downvote
submitted by ∗hayayah(1212)

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Hyperacute transplant rejection occurs within minutes d/t pre-existing recipient antibodies that react to donor antigen (type II hypersensitivity reaction), activate complement.

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mcl [Useful figures illustrating transplant rejection](https://www.stomponstep1.com/transplant-rejection-hyperacute-acute-chronic-graft-versus-host/) +

drdoom ^ via @mcl [Useful figures illustrating transplant rejection](https://www.stomponstep1.com/transplant-rejection-hyperacute-acute-chronic-graft-versus-host/ +1

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submitted by priapism(8)

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Per First Aid: antibodies against ABO blood types tend to be IgM or IgG, which is why the answer is IgG + complement and not IgA + complement

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yotsubato IgA also has no role in any hypersensitivity reaction +3

divya hi. where is this given in first aid? +

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