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NBME 21 Answers

nbme21/Block 4/Question#31 (reveal difficulty score)
A 48-year-old woman comes to the physician ...
Paracrine stimulation of osteoclasts by osteoblasts ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—tinydoc(276)
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hypdiraptesryHiorma gincaus eonb nsolsei si aiv saletoObtss cainrgnies ANKR L- sprenxsoie to bdin ot RAKN on cottssselOa nda msliittagun htem --&-gt; nic Bneo oornRpiest

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pg32  Pcedik D spdeite dageninstrnud eht aobve ^^ eucbeas 1-IL is osla nkonw sa loasctsote tncivigaita r.ta.cof. +8
plzhelp123  ^ I did eht mea,s ubt it eapsrpa ttah L1I- iaavtestc asesltotcso in lipmtlue leomyam. hchiW eamks esnse sa atth is a peoslnma fo imemun llsce hhwci nca cupodre eunntli.rseik +
caitlyncloy  nac ayenno apxenil yhw shit het saernw si PRN"AARIC"E untlmis?oait? I luer uto teh rcetcor aenrsw abseceu i asw putcigrni KRNA dan NRAK L di,inbng wcihh si otn rp!cn?raeia +1
caitlyncloy  .o.h it esem RANK L si redsecet to vaiattce het sac.sl.t i saw ntigruipc ti as KALNR aws no the ruacefs fo het .asblt ecrneef :er hOcweu./swRtaAo=Jw.tItwu:yb?s/ehtBvtech/opm +1
makingstrides  If ouy a,cn I uodWl hilyhg eemrcmnod iloognk ta hte sehckty ahmrp ofr it.sh It eapxnlis tsih e,llw ni ym ,oopnnii dan ineidyletf ledphe .em +
jatsyuk38  njGloa I e'vdolcu nowrs siad PHT astteimuls ttlsbosoase to tseeerc IL-1 to aecvttai el.oststocsa eH loas dsia ornetegs prnevset soooitesrosp yb iihnitignb aelboosstt eealrse fo Le..hovr.-w1Ie erhte is soal a roWUdl uotenisq ehrew it dias LNKA-R yapsl a more ritnatopm oerl rocat ovre( -L1I) in TPH diaemtde oben wkbardeon +1

Primary hyperparathyroidism: overproduction of PTH by parathyroid chief cells Effect of PTH on bone โ†’ increased bone resorption โ†’ โ†‘ release of calcium phosphate โ†’ โ†‘ calcium levels Induces RANKL expression in osteoblasts โ†’ binding of RANKL to RANK on osteoclasts โ†’ activation of osteoclasts Induces IL-1 expression in osteoblasts โ†’ activation of osteoclasts" Amboss

Not sure why D is wrong

+/- alexv0815(10)

Primary hyperparathyroidism: overproduction of PTH by parathyroid chief cells Effect of PTH on bone โ†’ increased bone resorption โ†’ โ†‘ release of calcium phosphate โ†’ โ†‘ calcium levels

Induces RANKL expression in osteoblasts โ†’ binding of RANKL to RANK on osteoclasts โ†’ activation of osteoclasts

Induces IL-1 expression in osteoblasts โ†’ activation of osteoclasts

Not sure why D is wrong

+6/- alexv0815(10)


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