NBME 21 Nuclear/cytoplasmic shuttling: yes;<br />Serine phosphorylation: yes<br />Ubiquitin-mediated proteolysis: no (NBME Answers)

Retired NBME 21 Answers

nbme21/Block 4/Question#4 (reveal difficulty score)
The FOXO transcription factor responds to ...
Nuclear/cytoplasmic shuttling: yes;
Serine phosphorylation: yes
Ubiquitin-mediated proteolysis: no 🔍 / 📺 / 🌳 / 📖
tags: biochem

+13 upvote downvote
submitted by calcium196(12)

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iabttUdnuedeii-iqm irsyltpeoos is not rvlyrbseie datecffe yb uil.insn hTe tsuqoein skas rfo esbverrlie syaw htat inlisun cstfefa t,i and oiutbquantinii loudw dlae to aengirtadod iva ,sstpoerae hhcwi is ton elseiberr.v tylpmauloceNas/ccri gnisnthu ekasm nsese uebecas OXFO is a npicotiarrsnt ,rcaotf os ti tnac’ od ist boj if it si ni teh at!mslpcyo

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meningitis hTnak yuo for yoru nto!iapalnxe n e O tq:eusoni woH abtou eht nrseei iotohpnpah?olysr Is it erwsdaen yb prue nemrazioitom ahtt het XOOF TF si eserni photlreash,ypdo or si it a erlngae ctaf atht lal Fs'T rae nr-nioeeiernsthe yrohp?dhtleapos +

tsl19 Im' tno usre, utb ti yma eb sa eimpsl sa i:hts e-iaditebimduitunq yleripsotos is ii,rerlvbeers ubt thbo C/N tsnulhtgi adn iayopopthlohnsr aer aylneerlg rbeiversle seecs.sopr +

didelphus I aols ugsesde atth XOFO utms be a tpra fo het P3IK ytaap,wh senci nniuils aegrsuetl mtseoamlbi thhrogu P3IK nad teh uitqseno setm efplciylsaci insnoemt .atth yoPhorhntipolas si a arojm arpt fo taht yapht,aw so eevn yidrcienlt hhpplsnoriootay lduow eeartulg OXO.F itsFuargtnr q.utosine +21

niboonsh ,yes XOFO is aedctffe damonrswte fo eht incvaiotat fo .3PKI Thsi si a yralle gdoo eidvo hatt nsapxlei het wohle csaaedc hoeusbwse/=wm9/ww:/cdy.3up?-tNt.t4wahctLgvo +2

alexb nArgiocdc ot ideawikip (Oo/a/w.Xerd1pswOgtinkpitiFi/:e/i.kh) otoopnaslyhiphr of XO1OF is elrsrer.vbiei shiT is ifnrrerge to aonrphlsiophtoy fo irnese dssiuree no FOXO by tA,k iwchh ccsuor in eesrpnos to .uiisnln But het EBNM awrsen sutesgsg 'sti erreblv.ies hs'aWt pu? +2

almondbreeze cuold ikwi be rgwno no paoysinphhlroot bineg irerilsbe?vre ciocgndar ot tshi r,teilac it si a lbeeirrves rsc:espo urlgnaeito of OxFo rtiitnnscarpo trafsco by bieelsvrre onrsployhoihatp dan ntaioclteay (0pt0c3ee1i06/m/e0we:wtc8e#e/rcii/t094r1snc7/w7doc1hna5psi/s1.Sici8.c0slt0me) os iwki onf,i ro,vewhe si hlpufel : nI ist opnrtpdys-ulhaeoh sttae, 1FXOO is dolzceali ot the une,sclu hreew it ibsnd ot eth iuisnnl sseprneo qceseneu etlcado in hte treopmor for guocsel p6hatseps-aho nad sarinesec sit tare fo tapsrrni.oticn 1XF,OO huogrth egnscriani onnipatsrrict of e-aho-plstphs6asocegu, dlyriietnc riensceas eth tare of phecait cegsluo o1]tp9odunr.ic[ woeeHvr, nhew OFX1O is oodpyelahshtrp yb Akt no -,42hTr 2Sr5e,-6 and -93,rS1e it si ceeuxldd mofr het nseul,uc hrwee it si tnhe tuduqitinbiea dna de.drdaeg ehT ayitopnhlpsoohr fo 1FXOO by tAk eebsultqyuns adeceerss eth hteicpa ulsogce urcdonoitp htgouhr a eeescard in naosrrtiinptc fo sulogce ahsho6t.appe-s +

leaf_house tI meess like eht holtrihoaopsnyp fomr Atk deasl ot ienotcdtus,r tbu emyba teh ionptumsas si atth ahtt tsoniphhlyrooap estp gdenlu(xci eyrve thoer estp of eobquotmiptuis-eoirn aptwyh)a si vlsreeerib, rhwee possrytoiel si ial.nf in o@hsnbo eodvi si oogd tub tnsoed' itlps isth eno. +

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submitted by ∗imgdoc(183)

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sThi ostuiqne si isnagk buota het nlsniui poetcrer oensirty eksani pay.awht oS keta ti mofr htere,

Teh phlhtoaornysoip of teh ISR istevctaa a iangls tdcrstanionu acdecas tath ealsd ot eht iaittcavon fo ohrte siankse as lewl as tnricaniprsto oarfstc taht taemide the lrtiaclrlaeun tefesfc fo lsnu.iin pCucalm/itroasleNcy gsihtnltu - esy rel)esi(brev
inrirnTohnSe/eee enasski are salo kwnno to uedcre het aitvtciy of sl.ininu - yes lebei)err(sv
iiqiutnUb - metaeddi ssyieoolrpt - no ont( erse),rbleiv adn laos nluiins aaelcllytbmoi esnariesc otinepr nstessihy os ti 'sdneto hmcat thwa slnniiu dose aaswn.yy

tcreocr em fi 'Im .orwgn

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usmle11a i nkthi yorue rtceocr csaue tuubiiiqn idedemat etyosriplo si na eirierlbesrv esp.t +1

+7 upvote downvote
submitted by ∗hello(429)

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eTh Q mste ttsaes XOFO is a tnrsrcpiiatno rtcafo tath dsopners ot inisuln nnlisaigg by igleartn eth tarrpniocsitn of ctbeliaom geesn &g-;-t e,rrfeheto OFXO si a inrpticsntoar tafroc nvlevodi ni embmlista.o hsiT hodlus ekam esnes suecabe noelerrspuiinc-t ntoivciaat ahs a olre in nraluigget amstle.biom

ihsT Q sska boaut lsebrreeiv swya ahtt nsniiul auetgres FXOO ntnripotscar tcoraf vayct.iti

tmdUieaqeiiunibdt- ootilpsrsey is lirvesrribee. nltmEiiae lal oeihscc peextc rfo ,B ,D dan .H

etrlnuIon-pesirsc tufocinn hoguhtr IK3P n.siiaggln IKP3 sngnlgaii vsnvieol lhihoypoprnotsa fo esnrei t&;--g ireens nopspotalihryoh is a eerisrevbl rspes.oc enaitilmE .H :FIY oiraipm/onten acdi orphoytpoailshn is wslaya .ereeilrvbs

Yuo are left ihtw ehsoicc B dan .D

OFOX si a tipaniroscrtn ocatfr ;-t&-g oncinttirrasp starofc ditmeae egen tyvitcia yb hltsutngi etbneew hte amclypost dna lncus.ue uantegigRl teh iconalot of OFOX rntascpiionrt ctafro (.ei. atsycoplm sv. sculu)ne llwi eetrofehr vyierblres modeault OteXOmF-deiad aoeltcbim eeng i.yctivta

iTsh leaesv uyo tihw the tcrroec r:wsaen ecCohi .B

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adong A brttee ywa ot hktin atuob it is linnuis cast ohhtrug PKAM ihhcw is a teiorierhnnes/ne anisek +1

amy I aenttepitedr cepalrylusNmc/otiCa ilthgtnsu dlouw be teh uetlrs of enrsei lsahpoootyi,hnpr os teh sbeliervre tcimnaoofdii is noly no neersi hpnoaol,tyipohrs hchwi dlae to olluritsanayccepmc/ ,slutihtgn tbu the itlghnuts eilsft si ton nredu doiatcno.ifiI m ogt it w.gnro +

+1 upvote downvote
submitted by ∗usmleuser007(464)

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reineS loyposnophairht ilwl dcreue ssiniu'ln ce.ffats It satc on eht rnsiteyo .keanis

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alexandramda /c2u./9pd7-n00btcfwlr-68mp0/wpiclS.or/o0g)-.etwesodh8flt(9/029:03y +

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