Quoting Dr Sattar, if an injury or cut is too deep so as the regenerative/stem cells are removed/damaged - then healing can only occur by repair. Thus, in this case, the stem cells of the lung aka Type 2 pneumocytes reside in the basement membrane - so, injury to basement membrane would damage type 2 pneumocytes and would NOT allow restoration of normal lung architecture. That's why maintenance of basement membrane integrity is the most important determining factor to distinguish whether tissue will heal by regeneration (restore normal architecture) or repair (fibrosis/scarring). Same concept can be applied to skin (basal cells) and intestines (crypt cells).
oYu veha to thnki buato ti hist yw:a the bnesmtae maemnerb si eth ginslaff“”dco no hhwic vret[rtsa]oie hgalien srcu.oc o,S eys, tesm llesc y(etp II ecn)euyosptm wdluo eb eionvdlv in taht enlahig ossrpec btu yhte d’nultoc eserort eht omnrla utirhaecctre (no“ ebno”it)aalmsir uthwito teh k‘’oneltes fo teh btemesna bnmeaemr iltegln tehm eerwh to g,o in what ncidtiroe ot w,org hhcwi awy is “,p”u tc.e fI the neteambs bnreemam si oderytsde, you nac llsit gte igae,hln ubt it n’two be zioeangrd ieglahn -- ’illt be dnagdzsoerii ieganh,l whhci sode ont rapepa sa rlmaon .iutess gzdaesirinD(o engliha is tbeter than no hegl,ian utb uhtwiot a M,B eth argriengneet elcsl ’otdn haev nya cnre“”itdio dna feetrohre atnc’ eerstro eth rlaonm iceaeutrrhc.)t
I luodw tihkn uriotnleso ioevvsln hte tesm ellcs y(tep II my.ncps)eueto Is teh tacitn tebnmsea eambmnre teh sreawn esacube ti lmtsii r?adsep
can aynnoe npeixla hyw )(D aeapaltism is ornecictr?
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