rveFe ;&-gt elru uto etfl ertuvrcnlai rlfeuai - MSTXPM orhipsxylap -t;g& lure uto cPmostsueyni iei jidovyKercn atspntanlr tub on CBWCB/R in riuen &-g;t leur uto pnrnlatsta rtonjceei

igveanL CMV dna platycai acermmyotcbui sa the iigarnenm tow o.otinsp CMV si mroe lielky in a plaatrtnns pnt.eati

saNeploia si nwe siutse whotgr atth is eadruutl,gne rsrebileierv, dna collann.oom

ntoCyllia nac eb meedtneidr yb 6cate-hloheps-ogups noyegraeseddh 6P)DG( mnezye sosro.ifm 6PGD si -dekXiln.

*rFo omre nifatriomno ehckc uto hC. 3 epsoaialN ni aomhatP

VL peospdt ok,wrgin repeussr dcabke pu noit mupl utcic.ir lmPu rticuic ygohulr si amde of 3 "tras"p - eht ,racapllisei atteniirlsti ap,esc nda hte vailloe.

nI cignicorade ockh,s hte xreat oobdl asisrecne aylpliacr isrodtatych peresrsu, ivrdign udfli otni eht trniaseliitt .paesc erapdoCm ot het voiella, het ratntilitesi apecs won sha orme idulf (tuhs eorm intietrtlsai hoittydcsar spreures dna elss intococ rssrpuee eud ot itaro fo ifudl ot ,r)teinop nda as a usetlr of shit cannbinlgua fo esfor,c dlfiu evosm iton eth aolilev ;&--tg ympnruaol dmeea.

gaeP 2 ash a egatr upciret

.n760wp(ipawt8-o04)t6c/60ls:9hgto9e.jw13cdn/l/S2/ir1i1ar-fe/

A ibg igthn ereh oot si gciniotn tath eth APL si e.dscderae ebstaoOstl ytavciti si edemasur by enob P.AL I itnhk atht was eth mina uoscf eehr adn otn taht yuo clesrinasey eedn ot nkwo eht 1FACB nege t.muaiotn

'eitastnP ypmmssto bgnea 30 mni trefa ogimnw awln i.e.( eafrt gndio ahslcyip )ia.tcivyt He hsa veesre chset pina dna is o,lco cyam,ml pcraeidt.ioh He hsa erecanisd rpoyumanl eyrtra rserspeu adn aederiscn fetl atilra rep.resus ankeT oertt,lgahe iths si riacndcgioe .kscho

rengcoCiadi koshc is a aerht mppu mlbproe -- eth LV snit' .ngrkwoi

henW eth LV, i'snt gron,wki it csaesu a kbac up in het coeiirndt isepptoo ot owh odbol nmloraly so.lwf ee,oerrhfT olbod wlli bakc pu in hte u.gsnl

hisT uasesc crsadiene pcilaylar atshyoicrtd seprreus ;&--tg tihs isdvre omer ifdlu onit the etmniturstii ;tg&-- stih ecssau ieeasdncr ianitlttrsie otchysiatrd resurspe g-&-t; rhtee is onw oemr lfiud anht rmnalo ni hte uttsitmreiin tg--&; htsi tacsffe eht onipter iarto hniitw eth simrtenitut -t;-&g itsh assceu dscrdaeee netitlirtsia niotcoc eepsrusr.

Yuo acn rossc tou the top ehtre newras ceihs,oc C,A,.B You notw eb eisrnogabbr inahntyg in teh PCT in isa'nnocf snerdom.y knioLgo at kpi,ahmeloay yptahmean,oir and ipopohypasmhaeht nw.o eyoakHlmpai nct'a be ccerort esacebu nvee uhtgoh smuaisotp si slot ti lwil be eoebrdabsr ta teh rtale kicht icsdngaen ploo nad if thta onsdet emka ,eesns het bdoy will sudjta orf wol rmeus mspiousat ubt vitaigatnc het /++HK upmp on lsec.l It nis't atenohmraypi ucsbeea at teh ontelgiclc dctu ppiliacnr lle,cs prtaoornbise iwll .rcuco isTh veaesl moaiatpheshhpypo as hte rrcotec and noyl ewsrna i.hcoce

hielW hte itmleefi rski ni eth gneelra ooulpntpia si stuj oebwl %,1 ti si 5%6. ni efsetiedrgr- eaitrsevl of tnptisae dna ti rsesi ot reom thna 0%4 ni otgoomcnizy tinsw of cfftdeae poeel.p ygiazAnnl lsccisa deiusst of eth gentiesc of zniipsecorahh doen as leray as in 3s19,0 rechFis ouseldccn hatt a rcceondaonc eart ofr hyssciosp of tauob 5%0 ni moiotcygonz nitws smees to be a cteaiirls iteasem,t hcwih is ngliiynitascf ihhreg anht ttah ni tocdiiyzg siwnt of aubot 10%–19 (Cibcmisn23c/h#apP/cenn6/ilt.gorv/36.54rmf9.Mel)

A201F9 apge 74: cIlle- seidesa iiso(lcnnu lcel elsimadsidoicopesi/su eypt i)—eIrihdentI maolssoyl togares ;oiedrrsd fedetc in eyclnclhisef1shoo-lpauntmt-oasyrrspgeNa-a ;rar&r efuarli fo hte igGlo ot hoatelpphrosy nenmoas srsuedie igo(fnmr hmt-a)sepon-h6osepna no orgeoylnscpit r;r&ar itpsreno rea decetrse utxllreelylacar terhar tnha evdielred ot slssey.oom tulseRs in ceraos lfcaia rfes,uaet ilginavg yrpisahepl,a culoedd co,rensa rircdetets itnjo mnem,ostve lcaw ndha retifdiosm,e ois,hokscislpoy dan ighh lmsapa velels of sylomalso ym.nzese nOtfe aftla ni chioldoh.d

lAso orf hsteo of uyo who aer ltlotay llesecus ekil ,me ruriayn tctra bitcuorosnt = rvibotesutc thyura.po

hrewNoe ehva I nbee leba to ndfi yhw eht ehll tshi is a itgh.n

nseMsise utisanotm invloev a centeodlui tsotsuitbuin rlntsiueg ni dchgnae oamni ic.asd mtSeseoim het tfeesfc of sinsemse utmtansoi mya eb lnyo perpatan dnuer renctai notveelaninrm niio;stdcon cshu essmiens asnioutmt ear lcelda odctanlinoi u.aitmsnot Mnya emisenss tsomuinta tslure in sepnirto atth rae illts n,ulniaoftc at taesl ot semo .eeedgr

,osAl all eth ertho resnswa wudlo rybplaob elvae yuo iwth eterih a atryegl ltardee ro tonn-aiocunlnf tipeorn.

dBifi cdrotia epssul rea nees ni rcotiA stoeisns or orturitneigag

tadrioC Bruti is redha with csthrelarsseoio fo mmcoon tdaciro eytrra

owlS igsrni aeedredcs mleuov adioctr suelp is cciaarsrteciht fo rocati io.stnsse

Cnnnao wesva era seen in ctloemep VA cl,okb as thirg vetlncrei nad traai atotcnrc yinel.dpentned

lzIotceaonar rquirsee eht dccaii ioeemnnrtnv of teh matcohs ot be sbaboder. oeOmlzraep tisihbin eht /+H+K mppu fo eth hmscot,a hetyrbe dericgnaes hte taciiyd of het hmas.tco So nhwe teh tantipe astek mlreaOzpoe and conazerIlato t,ehetgor cnealtzIooar wot'n eb baordbes otin eht bydo. tsa'hT hyw ti ash on ecffet.

t'Is odmrdceemne to aket nmsiaidetco ta elast 2 sruho rpori ot itakgn an dtaci.na

sThi irlg ash cexreeis ddiucne tham.sa It si tno wlle utoonedrds why ti hnsppae but teh grtgreis aer dgzienr.eco yaormlNl hnwe ignhtbrae ruoscc ari si nekat ni yb hte eosn and eth salan spasgsae dna niaestbtur tac to ovrmee tdsu adn i/wmfriymahdu eht ra.i Lyiolgcla hits seamk eth air erdsen TP.vnR= oS ewhn eierxign,sc benaitrgh rhthguo the esno is erecdeasd nda ecparedl yb rome rusgvooi tumho erta.gihbn hiTs emans teh air si ton edfdhiumii nad waedrm up. heT air is slse deens adn the ahasmt .usnsee Teh untisqoe ktoo hist mase lirpiecnp ptecex erervsde it yb ikgasn twah lnxrtaee ncnodtoii odlcu aled ot het sahatm dna htat wuodl be lcod dry ai.r

yiAmten yuo ehva a oserpn how psubm irhte hdea, sgte bcak u,p dna hetn sah vesree sseuis or sdei ikle 6 rhuso laret -- oyu vaeh olfysreu na druapeil maeamtho frmo taairnecol to teh edmidl NEMGNIAEL .rearty jlnoGa( lrayel zesesmpiha atht uoy d'nto esrwc pu dna ltcsee mddlei )lerbe.rac oYu owkn ti ahs to eb an rletiara ianreaoltc insce het arud is lgytthi hdedrea to teh u'llssk nnire afc.urse Gljaon edrreefr to ihs ieneeeprcx wtih it as gdeeinn reilps ot omvere het adru omfr het kll;us acpr,hgi utb it ivsdre hte tnopi hmo.e tgiTnen eens on TC is beueacs teh riluaped amaoemht sgte sctuk enwteeb het erutsu ls.nie ehnW ti gmnaaes to kerba psta eno fo eht uteurs eils,n it si ym nnguaddrenist htta etnh si wenh you teg eevser ulsaeqe,e elki atehd ro watehrve.

nDurgi teh tasl fhla of aeprngycn alditnoi fo teh eprpu rnuiyra rttca can ucrco ude to rseinsopmco fo eth tuerers yb hte owignrg t/rueueustfs nad het liena masti.eirln The pnesioorsmc fo heets si otn onwgllia uldif gaepass onti teh dlrdbae uaiscng runei ublpiud ni het ,yndkie thsi dasle ot doiatiln of teh ndyike thta ndes up sngaicu spymiottamc ssrnrihhdeoo.py hsit cna dne up ni ctifonein dan tommysps chus as teh osen ternspe ni tihs nittape kiel kbac niap dna VAC dsstene.enr eth ngrcyi is nymial eud ot hte nipa eudacs by the rtutcbos.oni na d stuj as imgostehn rx:eat lubdeo itpigal hertaestc is a asef adn slmipe way of argnttie tymscpatmio phnrhdrooiyess of gp.rcynena

cTcairho udct nerl.sitoa

Gljnao dah a utceerl atth mnndoetie htat "fI a nptteia ash laahorgcre,ta weveri revye udgr yetre'h iktagn iesnc myna usdgr ecsua olrcraat"ageh.

heT olyn hgtin of obslespi ealveencr ni ihst tmesQ- si ahtt esh steka a iaot,necidm eteofrrhe eht eanrws fo gdur" ef"ctfe is het mtos kielly rnesoa orf hre oarhaeraltc.g

=hochnyooprnB nx Eynrmtpouareaipio st=rdiro iroabhoahlnctecr nsrctuioobt eingao/r(smfs nopa iIobtdsrr)yy rstdoir = egnyrlala icn urouscutosbcsiSnot h=saslp etts for rpolyic sntosies

Wenh ehetr is a cfaertdur ibr ti will uscea a turama otnhompexar ihhwc nca ceaus ria ot secpae nda ocmbee eptrpda redun hte kins laeidgn to ucsti.rpe

hsTi si a aoniioltncd ecdlal ldicpcasrnoaysdilaoei. The kdi on etgSarnr nghsiT ihtw the ilps sah the rse.ioddr oN acroll b,nseo oot myna h,teet noalftr bnsiogs g;=&t odassdlaypioairlniec.c BF1CA is a egen yhlgih icdilmptea ni oelsobsatt .fctninou

cirvol,Acy vcriaocli,fm yoivlalvrcca ear gnanosuie aloa.sng eTyh regdoun nneorvocis to cyavliorc hhptomspeanoo via uvrsi ondecde eit-mdh.siineynka iay,Utmtlel ethy tiibhin livra DNA mapeesoyrl yb hanic irett.niaonm

tdutMea vailr ihedtniym ainesk nac eucas tiscernsa.e

eWhn nsadntig up, het bdyo lonmrlya ttsaaiecv scyetahmpti yessmt to odvai htcotastrio honpsiteon.y

tuB nscei heter is own na viddetia eeftcf of het pocorthmhacymooe e,gcarindesr ti llwi dael to a hretioepsnny

.(i:e Deboul sncirosatvncoito = hoPe agrieescdnr + temScpthiay tsymes)

animiAstnotdri fo lniiecilPn fro ihilSspy may laed to hte exs-JHhceraiemhirr taenroic hruso aetrf ee.rttatmn cucrsO deu to lysis fo ociesphrest so( ti cna urcco ithw rlBraoie adn osLeitorsspip sa .lelw) hTe rcieaotn is rdeczaatierch yb eefvr adn chills.

Teh calsslaci ixlenonpaat of the eeirmrHexh anoeirtc si that mnteeartt lrstuse ni eth dusdne dteha adn uosdictnret fo rgeal busmner fo e,mpersotne htwi teh rieilnbtoa of reotnpi oturdpsc and .onxist

nticciA paruurp ulsster rmof rntvaaoseatxi of lobod nito eht md.ersi hsiT npooenehmn is deu ot eht kins trahoyp adn eht filtirayg fo hte lbodo lessevs ni rydelel iianvusldid, hwhic si aebetecdrxa yb ohcrinc snu p.ousxere cAntici rpaupru oeissnl aer atelodc no nspx-uesedo ,resaa ilek hte asr,m fa,ec dna en.kc

niSk ahyprto ni ermitrdspsoaoo is eud ot an tairltnaoe fo llceg,nao iiarsml ot htat cwhhi si snee ni rp.siostosoeo iThs codurnnpoe insk aoythpr uedsac yb eth hpggnao-tio seamk the redalm avcurasl kotwner rvey etnsesivi ot hte ihgesltst tmraua or ngsrheia ocerf.

sA aetstd ew,olb teh tefL rcus erirceb asw agddema e(es hatw it uhlsdo mlarylon look klie o)webl. Tish inoantcs het priiltnccooas ttcra. cSein het ispococrlatni catrt eaedcusst at the ldulmae, eowbl eht arnmiidb neiocts ewr'e gloiokn a,t ouy dwolu ees teCalranlarot hgRi(t) Sisctpa msaepsHirei

ctaiisDbe get rpaherlpie euynhaprot romf uesgclo daagnmig ncwhSan esl.lc rFo ahwt I eeilebv is na fmdnneuocri a,oresn MD2T ntasitep ndte ot ees hrmaeitpatycasp tcuonimoa pnrhatuyoe breeof yitcmtap.hse

Teh osytagphric erevn ascrrei hetsacmyipt anrtnoeiinv to eht soprertio earrtuh nad si iesprbnoels for a.cjialotneu

oeIrfnir aletrc enrev si a chbran fo eht epnddaul enrve ttah annrsvteei eht elarexnt naal npiercsth dna pvirdose oastsnnie owlbe hte aectpnite .nlie A rephaeplir never omerpbl with hsit evenr udwlo ceuas het nhscrtiep ot eiarmn rdaexle nad esuca ecocnitennni, tno sao.tiptocinn

vilecP nnpacicslh ersven rae ipeatasthymsrapc asoccarari(nl uwoo).lft If eh si dapcniots,te ihs rset and isgetd apyetsc(phm)itaar symest is ton iwgkrno.

laeirneP nvere is a hcbnra fo eht duapdeln ve.enr tI sah hotb omrot nad n,orsyse is liovednv in teh nralteex laan ipench,rts lerhruat ptnhcs,rei nad si oeinsprlbes fro ucosocisn ensotinsa of eth deen to tnrua.ei

arcaSl thicatmsype nihbitsi ,sstelsirpai dna cttacrson rtielnan anal ehncritps ot aiitmnan cencei.nnto

yeivstiSnit tstes aer dsue for eng.rniesc ccpfiyeiiSt tsset aer esdu for iontiafomnrc frtea vtespoii grncesn.ies

seiyititSnv estst are esdu orf geneis owh yamn peoelp yrutl vhae eht i.ssedea itecSipciyf tesst aer rfo sthoe woh do not have the esidase.

A hyhgil esnietvsi te,ts wnhe ,eengavit slrue OTU disasee. A ghihly icecsfpi s,tte ewnh osiietv,p rlesu IN esdes.ia ,So a ttse whit wtih wol itssenivyti natonc leur out a de.iesas A tset whit wlo yctcipiisef ca'tn erlu in aedss.ei

hTe codrot nad tintape awtn to ecnres rof noloc rnaecc nda elur it tu.o ehT trodoc doluw awtn a etts ihwt ihhg tyinisteivs to eb aelb ot od .tath eH nwkso htat gnittse her losto fro obldo lilw ont lrue tuo eth spliyoibist fo cloon C.A

Teh nmecmion I ikle orf nmeierrgebm teh caitslono fo the ialacnr renvse si teh ,,424,"2 "luer

evoAb n=bimrstae NC I + =r nMaIIbiid CN I,II sn=V IoP CN V, ,VI ,VII V=aeMIudlII l CN ,IX X, ,XI XII

A rrdicligpayahalo lisbevi idrulia-f elvle eussstgg a ttprye egarl nelios eh(cne, tyvr”.aa“)ic thT'as not niogg to oecmbe nlrmao etisus aai.ng ixS hsomtn ofoglnilw tnelsurooi of tmsypoms yuo anc tpeexc ealnghi in hte ormf of a ;acsr htat is, iosfsrib tub yonl in a glensi op.st

niuoMtats in -1TMTL ono(lidyhtclrMai eddceno tRAN eenciul )1

A nomocm taiuntom si 3.43AG2 anC trules ni leiltpmu lrntmihoadoic dciisifenece adn aetcsisaod sod.desrri tI is tdocaeasis t:hwi

• doitahcrMioln omyahnpeyptleoahc
• tccaiL iasciods
• rS-etkioekl eidespos (ASELM)

LMAES si a rera dtclnomiahoir disreodr nnkow to tefcfa nyma tsrpa of the odyb, eplcelasiy eth revonus mtyses nda het rbin.a pmoymSts fo AELMS :ciedlun

• rutecnRer eevrse ecdshaahe
• cMseul keewssna yy(mtop)ah
• enHgari loss
• koStr-kelei edspiseo htiw a lsos fo ,ucescssioonsn isusr,eez nad rhtoe mseobprl ffaniegtc eht neousvr yss.etm

euo:cSr npr1dwsat:k/ig/wii-pT/t/kM.ieo.hLeTi

As cesdedibr in teh teuoqisn ,tmse isht uanmitot roucsc ihintw an rnoint a( egne mstegne whhic si irdestanrcb -AtD[;RNAN&]g but otn )lsedrt.naat ANR lipingcs ne(z)seym abgr ARN and l“oop it;” an nitnro si ctu tou nad eht snxeo no eerhti esdi of the ntroni aer edji,dnoa ielk stih:

1oe—t2nro—nnoeixnx g;=t& eo1o—ex2nnx

lpTya,ycil htsi ipgiclsn soccru ta het eryv sgdee of teh onrint awht( I doedent iwht the —”“ rrch)aaet.c tBu in uro ,seac a aotiunmt whniti teh rtnion si csainug RNA sigpnlic eyznem ot ngceerizo a new it:es het irclpes stcu nwithi teh inrton iatsde(n fo ta eht yvre ge,de sa ti ld.o)shu S,o ew gte otnghmies atht slkoo liek shi:t

xn—1—erninxeot2o

ashtT’ a tolatly entfridfe RmNA ,ecumolle nad i'ts nogig to aekm uro liβgon-b etpoinr loko (and vah)bee alfwyul atnse.rg

sTih is a yerv iipkyntc .tieqosun As I ees i,t hte 3 nmai tpocsnce edtset rae:

• iTsh epitant sah tareilnigm aeraulnig ,pr(ahs brfie, ocdpiies niap in eth ,ae)cf hichw si ceauds by a olensi ot aprrymi syerons ribfes that cyrra anpi astnnioes fmor eht fcea.
• elpMlitu ssilrosce, hihwc teh atitpne s,ha si a ylninmeteaidg isdaees ,..(ie it atcffse etihw )e.attrm
• ehT liymatdnee xaosn cnrairyg naip tnsneoais orfm eth aiptrslaeli eafc tnree the btesmiran at teh velle fo eth npos nda thne deendcs m(eeobc teh lasnip atctr of the gmtelirna).i eesTh twehi tmrtae sefbri spsa ohruhtg eth sonp to nssyepa on eth asplin csuulne fo het mtaegn,iilr cwhhi si in eth uamleld euslucn( = rgay mtear).t (ructepi heer.) T,rerofehe a ienlos in eht wihte aermtt ,.ie(. pa)qlue ni teh opsn uolcd uecsa elrniamgti egaiul,ran dna this nmneneooph sah bene dveresbo.

obvAe the lelve of het aibtsemrn mt(lsahua m;&pa rarelebc ),tercox uyo veha nedocs oedrr osryens nnrsu.oe osniLse in isht tpra of het crctiiu rea ont ryelgenla ni agletmnrii n.legaauir I epousps htey lsoa wtna us to sasmeu ttha once teh apnils rtatc of eth milrtgeian tnrees eth lmdla,ue ts'i ont leeanmiytd yr.eonma I tond' hnkti sthi is lmeeoltcyp u,ert tbu givne eht iclgo sredeidbc aevob, nspo oduwl llits be eht erebtt wa.rsen

As lpeeop haev dntioep ,out hte rrpaymi eoyrssn bfsier rirayncg litgh tochu sonasetni ofmr eth cefa neyssap on eht ceifh yeornss sceulun ni teh sonp eiyteadmlim ftaer ehty eentr eth pn.os siTh qtsnueio si ont asnigk botau toesh irfbes .toghhu

I tog eht unosqtie gnwro to.o.

natitraCooc fo teh toara elsad ot saedrcine VL voerdoal gnacisu LV yehyrrhppot dna a L axsi tivodniae.

Teh ywa I phocdaepar hte queintos aws to erdsocni awht hspnaep 1. neWh oyu orwg ofrm a ybba ot a hc,lid and 2. whne uyo ogwr rmof a eeetangr ot an eolrd t.dlau vaehWert dnmreeai rteu neebtwe ohbt fo thme was het gtirh .erwsan

gRtih an:erws eh T erintsg BP fo a bnenwro si 054/6 ologg)(,e wheli htat fo a 1tmnh-o ldo si 60.9/5 hTe aareegv lduat is g,ihher wthi het aniAcmer Hrtae aitnAssooic citnig badrs,(lyu M)IO that rolnm""a si t/0;l0t1;2l&&8. tslhevreeNes, het nerdt is that BP recnsieas sa we ae,g rweehht we rae srnenowb ro odl poepe.l

gnWro :nsrwsea eD nlptmoeev of ncaoyorr taleohcosrs:iesr rhepaPs deu to hte nirAmeca ited it anc eb ruadeg that het etneepdmolv fo aolhcsrsiostree is tomsla tevlinaeib as uyo oebemc an rledo .ldaut ieCnaytrl tno uetr as a byba -&-tg; lh.cid

otDnvmeplee of imalrt :neotssis imlraiS iongsnera as arrooycn eortcl;eosirsahs uoy YAM poelevd ti sa na talud (nto yenlar as comnmo as a uduilpb fo crretotsoaielhc ql)eusap, but eu,sr 'tsle yas htta it anc ppaeh.n otN urte as a bayb &--;gt hicl.d

dencIrase lsbaa htare r:tae heT pooetsip si ctluayal tr.eu eTh blsaa areth atre fo a nonbwer anc yesali cdxeee ,051 nad 'tsaht onescreidd l.amrno sA ew ga,e this rhtae aret egos nodw.

aeedrnsIc rcaaidc lsecum :msas hsTi neo asw het rshtead to krow .utrhhgo It si urte htta sa we gae rmof a bbay g&-;-t ilcdh ruo rahet srgwo ni sei.z tBu if ew wetka rou pimoasstun mrfo orefeb twhi eht Ainmrace d,iet adn aesdint tup our etianpt no a orem eeotmdar tie,d aliyesralitlc ihs areth udnstolh' naeseric in izes oot h,mcu at stale ot the nipto fo gydrace.lmoia

edseacrnI conleaimcp fo rte:earsi sA ew ecombe ldroe ,dsatlu hte lncmpieaoc of arertsei seredecsa dan sssfifent eiraencss ulfc(are ont to enufsoc eatirrse wiht u,sgln ihwch yctlaula od raecesni in nceimapclo sa ew gea)!

eUs the HgerWieab-yndr tqinaoeu

1. kaeT eht eausqr roto of 06/011, dan htta lilw veig oyu het runyeceqf fo eth vseeicers leeall = 1/40.
2. acetlaCul the nuqcryfee fo eht mtdonani leeall thwi =q1p,+ hwihc is p= 9.705.
3. yThe aer ltlineg yuo to acletluac teh eunqryfec fo teh seaesid rscra,ier chwih si hitw het eqitunao 2.pq
4. yehT atnw nloy eht deiseas iaerrrsc ni chhwi etdleoni si e.nrtpes oT uaaltcecl thi,s seu het q aeluv /04(1) adn myiplltu yb 0%8 ni hsti hsdlou vgei you ..002
5. ,yFallni cllaucate fro 2q 2P (509.0.)=)(270 .400 = 152./

,solA uyo l'udhtons eb enseig dga-nneor admaeg or crienadse nerni / edkyni roepsnes ithw a ruplvseoiy hyhetla ietapnt atth stuj odvedepel etnsailse .NHT heT oydb dsneto' nawt to airsceen rneni hnwe it ahs .NHT Hwoee,vr if ouy ahve no,seists the diyesnk rfkea otu beausce re'htey tno iegttng uengoh ofwl and htkni hte hlewo boyd tins' retehi, so ethy ceiaattv the AASR mysse.t When uyo vieg ehtm na A-CIE, hte rnien is llist iebng cduedopr yb hte enky,di ti jsut ni'st gnbie nedotcrev to tnIa.-nIisgonei

oT mleeitnia htreo :ecishoc

• He sha inedacers renin itviycat so ouy cna timelinea rpmayir itdnmorsleosa. Thta ahs in.c tonsdraoeel, .cde nerin.
• No snsig ro sxs fo usiC'hgns os ttas'h neitiea.dlm
• 1yrsaBh-olyxd-1e icfdcneiey odlwu ssx hitw eth nlitg.eiaa Yd'ou ehav ce.d irenn ictaviyt losd-e(ketrinoael cfeefts slilt .)ntespre
• isElesatn NTH: epdienxal vobea

teMlhoan si icotx by two m:nsemsihac

,strFi leomhtan acn be tlaaf ude to its CNS tnadsrpees risoeeprtp ni hte saem rmanne as hetnalo ig.nnspooi

oScnde, in a ersocsp of itacotxoi,n it is oeildbzeatm to fomicr aidc iav edahdrymfelo ni a soecrps taiteiidn by eht zeymen oholalc hsdoayrgednee ni the .vriel atlMhneo si cvrdteeon ot adefydmhorel iva alhoclo gryhdsaondeee )D(HA dna yledmadrhefo is nrctdovee to crmoif ciad rot)(fema via hdlyeead ehdaeneygsrdo AL(D.)H

Featmro is iotcx beauecs it tniiihbs radinhooiclmt meorthycoc c aosdeix, acsgiun yioapxh at teh ecualrll evl,el and bietmaclo sas,cioid mgnoa a terivya of ohtre acoiblmte .sansrtciudbe

nattePi sha a gaaonraioinmhcrpy. Mtos cmomon ocoddhhil ruaneoitplstar ortmu. Drvedei rfom nesrmnat of hRketa ucpho (aolr o.)tcdemer iaifcoltCanci si .omcomn oCelherotls alctssry ondfu ni toorm“ e”oilkil- ufdli iwihtn tmr.ou

A stcciy rrapslusale asms wtih faocnlcsaiitic and nmteeennach fo eth alwl or oilds ipsnorto in a lichd ro oastcdenle is oasmtl slyawa a miaghcranrypoian.o

ayM be snfdceuo htiw rtpiyatiu eaadnmo bth(o usaec oapleitrbm oh.epiia)mna

i'caFsonn si a lzeadreneig sobrotnpriea deetfc ni PTC singuac adrcesien ecxenoitr fo inamo ds,aic cls,ogeu O,–HC3 dna 3–PO4, and all esnuabcsst esbdroebar by het .CTP

isTh si taercive ylhamyceitop era,v hwich is eud to hghi utilaetd ro lngu isee.asd Sa2O si ,wlo nda PEO is dr.incseae

otneArh ywa ot paacroph eht etqounis is iglkono ta eth doolb msear. Is't trtpye anrolm n(o ymaegoscye,rkta no dcaesiner ubrnme of ets,ptlale no ,odsr thignno u,ebl cte). A dbolo smera omfr a DCPO antpeti lilw eb lrom.na Jtus na cinraeeds rbneum fo sCBR due to hte isenardce PEO adlngie ot aceresdin .bHg

iLrve okslo ytetpr -neosiazmdrl ot me. iPc ereh rfo rimpcaoosn

nI drroe rfo a udrg ot eb lcedrae yb the ykend,i it sumt tifrs eb elftdire in eth roeigullm. usDgr hitw a hhig VD hvae eomr fo hte ugdr in hte ieusst that rae ton laealbiva ot leidtref yb hte eikdy.n grDus hitw ighh iptnroe gbdiinn wnto' be dflereit ir.eeht So yuo natw a urgd itwh owl Vd dna lwo ndinibg fi ouy ntaw ti ldeearc avi hte sdkiney dan r.euni

921FA0 p 573 on tGiietrnasanlsot odlob ypulsp and rttcyaimahapspe toranneivni:

• eoFrtug &g;--t laeicc ytrae,r guavs itnvairneon
• tuMidg ;g&--t ,SMA uvags
• ditnHgu -;&g-t ,MAI plveic iirenonavnt

I oeshc itsh llesoy sabeuec it swa so amnd pscefcii

thetxeoeMart duwol be a drug of ochice orf ssprasioi crarorefyt ot ilcoatp mcesar dna tligh rea;pyht tibinish iodheyofrldta tadrsceue ni rrdoe to aeedesrc snki lcel roolretinfipa nad ecrued mfoamtnyrlia possee.nr

The yohoigslt si of cheoteysrsp laml(s psleiahrc cllse w/o elnacrt lo.ap)lr eadHrryeit sprsyctooiehs is deu to ecdetf ni otnieprs ngtrciianet with BRC bemmrane otsneekl nad lmsapa rmaemneb n(yin,akr adbn 3, oiptenr 24,. is.ncpr)et sMtlyo suaomalto tnnaodmi hatreinince (so eureooyzgsth atotminu encis ouy lnoy eend eno tnmuta lleeal ot etg het .)sseiade

lentulee-eybMh dsieatn fecla amres ldveeer onreusum tihlusrenop ub(t nto nay ga)sm.ronis ialeSglh is roecllsso wehn satiden twhi elemeyhnt u;elb E ocil ssatin ubel thiw nlhtyemee uble eebausc it refemnts tsaoce.l