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NBME 20 Answers




Question#4 (reveal difficulty score)
A 50-year-old man is brought to the emergency ...
Formic acid πŸ” / πŸ“Ί / 🌳

Question#5 (reveal difficulty score)
A 24-year-old African American man comes to ...
Pseudofolliculitis barbae πŸ” / πŸ“Ί / 🌳


Question#7 (reveal difficulty score)
A 5-year-old girl with AIDS develops a ...
Thymidine kinase πŸ” / πŸ“Ί / 🌳


Question#9 (reveal difficulty score)
A 50-year-old man is brought to the physician ...
Pick disease πŸ” / πŸ“Ί / 🌳



Question#12 (reveal difficulty score)
A 72-year-old woman with dysphagia is ...
Right kidney πŸ” / πŸ“Ί / 🌳


Question#14 (reveal difficulty score)
A 28-year-old man who is a migrant worker ...
Psoas major πŸ” / πŸ“Ί / 🌳


Question#16 (reveal difficulty score)
A 30-year-old woman with multiple sclerosis ...
Pons πŸ” / πŸ“Ί / 🌳

Question#17 (reveal difficulty score)
A 50-year-old woman comes to the physician ...
Drug effect πŸ” / πŸ“Ί / 🌳





Question#22 (reveal difficulty score)
A 38-year-old woman comes to the physician ...
Vagus πŸ” / πŸ“Ί / 🌳

Question#23 (reveal difficulty score)
A 34-year-old man who is HIV positive is ...
CD4+ T lymphocytes πŸ” / πŸ“Ί / 🌳

Question#24 (reveal difficulty score)
A 50-year-old man comes to the physician ...
Omeprazole πŸ” / πŸ“Ί / 🌳

Question#25 (reveal difficulty score)
A 25-year-old primigravid woman at 42Β weeks’ ...
Phosphoinositide hydrolysis πŸ” / πŸ“Ί / 🌳

Question#26 (reveal difficulty score)
Serum cholesterol concentrations are measured ...
16% πŸ” / πŸ“Ί / 🌳

Question#27 (reveal difficulty score)
A 53-year-old woman comes to the physician ...
Schistosoma mansoni πŸ” / πŸ“Ί / 🌳

Question#28 (reveal difficulty score)
A previously healthy 16-year-old girl comes ...
Trichomonas vaginalis πŸ” / πŸ“Ί / 🌳

Question#29 (reveal difficulty score)
During an experiment, an investigator ...
Lysine πŸ” / πŸ“Ί / 🌳

Question#30 (reveal difficulty score)
A 33-year-old woman comes to the emergency ...
Lunate πŸ” / πŸ“Ί / 🌳

Question#31 (reveal difficulty score)
A 66-year-old man has had fatigue, shortness ...
Focal pulmonary fibrosis πŸ” / πŸ“Ί / 🌳


Question#33 (reveal difficulty score)
A 17-year-old girl comes to the emergency ...
Mitochondrial πŸ” / πŸ“Ί / 🌳

Question#34 (reveal difficulty score)
A strain of Escherichia coli produces a ...
Missense πŸ” / πŸ“Ί / 🌳


Question#36 (reveal difficulty score)
A 56-year-old man is admitted to the hospital ...
Rhabdomyolysis πŸ” / πŸ“Ί / 🌳





Question#41 (reveal difficulty score)
A 45-year-old man has fever, chills, dysuria, ...
Escherichia coli πŸ” / πŸ“Ί / 🌳





Question#46 (reveal difficulty score)
A 55-year-old woman comes to the physician ...
Cholecalciferol πŸ” / πŸ“Ί / 🌳


Question#48 (reveal difficulty score)
An otherwise healthy 4-month-old girl is ...
Spontaneous involution πŸ” / πŸ“Ί / 🌳


Question#50 (reveal difficulty score)
A 26-year-old man undergoes an abdominal ...
Splenic πŸ” / πŸ“Ί / 🌳


Question#2 (reveal difficulty score)
Following a wedding reception that was ...
Norovirus πŸ” / πŸ“Ί / 🌳

Question#3 (reveal difficulty score)
An investigator compares the DNA sequences of ...
5β€² CCGG πŸ” / πŸ“Ί / 🌳



Question#6 (reveal difficulty score)
An 18-year-old boy has just been diagnosed ...
50% πŸ” / πŸ“Ί / 🌳


Question#8 (reveal difficulty score)
Three elderly residents of an assisted living ...
Legionella pneumophila πŸ” / πŸ“Ί / 🌳

Question#9 (reveal difficulty score)
An otherwise healthy 16-year-old girl comes ...
Cold, dry air πŸ” / πŸ“Ί / 🌳



Question#12 (reveal difficulty score)
An 80-year-old man with type 2 diabetes ...
Pelvic splanchnic πŸ” / πŸ“Ί / 🌳



Question#15 (reveal difficulty score)
A 55-year-old man comes to the physician ...
Dextromethorphan πŸ” / πŸ“Ί / 🌳



Question#18 (reveal difficulty score)
A 65-year-old man is brought to the emergency ...
ST-segment elevation πŸ” / πŸ“Ί / 🌳

Question#19 (reveal difficulty score)
A 66-year-old man is brought to the emergency ...
Cigarette smoking πŸ” / πŸ“Ί / 🌳

Question#20 (reveal difficulty score)
A 19-year-old man who is a college student is ...
Subcutaneous crepitus πŸ” / πŸ“Ί / 🌳


Question#22 (reveal difficulty score)
A 44-year-old woman comes to the physician ...
Ubiquitin ligase πŸ” / πŸ“Ί / 🌳


Question#24 (reveal difficulty score)
A patient with a 1-week history of diarrhea ...
Decreased arterial Pco2 πŸ” / πŸ“Ί / 🌳




Question#28 (reveal difficulty score)
At a postnatal checkup, a 6-week-old female ...
Annular pancreas πŸ” / πŸ“Ί / 🌳

Question#29 (reveal difficulty score)
A 25-year-old woman has a flu-like illness ...
Picornavirus πŸ” / πŸ“Ί / 🌳

Question#30 (reveal difficulty score)
A 78-year-old man is brought to the emergency ...
Cortisol πŸ” / πŸ“Ί / 🌳


Question#32 (reveal difficulty score)
A 12-year-old girl is brought to the ...
Osteoblasts πŸ” / πŸ“Ί / 🌳

Question#33 (reveal difficulty score)
A study is conducted to assess the effect of ...
Lead-time πŸ” / πŸ“Ί / 🌳

Question#34 (reveal difficulty score)
A 28-year-old man has excessive thirst and ...
Hypothalamus πŸ” / πŸ“Ί / 🌳

Question#35 (reveal difficulty score)
A 36-year-old woman comes to the office ...
Splenomegaly πŸ” / πŸ“Ί / 🌳

Question#36 (reveal difficulty score)
A 31-year-old man has a large, yellow, soft ...
Liposarcoma πŸ” / πŸ“Ί / 🌳




Question#40 (reveal difficulty score)
A 70-year-old man has a 3-month history of ...
Squamous cell carcinoma πŸ” / πŸ“Ί / 🌳


Question#42 (reveal difficulty score)
A previously healthy 32-year-old woman is ...
Preload πŸ” / πŸ“Ί / 🌳

Question#43 (reveal difficulty score)
An 18-year-old woman comes to the physician ...
Ovaries πŸ” / πŸ“Ί / 🌳


Question#45 (reveal difficulty score)
A new antiplatelet agent is developed for the ...
8% πŸ” / πŸ“Ί / 🌳


Question#47 (reveal difficulty score)
A 35-year-old man comes to the physician to ...
1:4 πŸ” / πŸ“Ί / 🌳

Question#48 (reveal difficulty score)
A sedentary 50-year-old man with hypertension ...
Antidepressant therapy πŸ” / πŸ“Ί / 🌳


Question#50 (reveal difficulty score)
A 27-year-old woman comes to the physician ...
Pheochromocytoma πŸ” / πŸ“Ί / 🌳

Question#1 (reveal difficulty score)
The frequency of an autosomal recessive ...
1/25 πŸ” / πŸ“Ί / 🌳

Question#2 (reveal difficulty score)
A 23-year-old woman is brought to the ...
Xanthine oxidase πŸ” / πŸ“Ί / 🌳

Question#3 (reveal difficulty score)
A 45-year-old woman has a thyroidectomy ...
Calcitonin πŸ” / πŸ“Ί / 🌳

Question#4 (reveal difficulty score)
An 18-year-old woman comes to the physician ...
Reactive T lymphocytes πŸ” / πŸ“Ί / 🌳

Question#5 (reveal difficulty score)
A 35-year-old man comes to the physician ...
Methotrexate πŸ” / πŸ“Ί / 🌳


Question#7 (reveal difficulty score)
A 10-year-old boy has a palpable mass in the ...
Endoderm of foramen caecum πŸ” / πŸ“Ί / 🌳


Question#9 (reveal difficulty score)
A 62-year-old man comes to the physician ...
Prostate πŸ” / πŸ“Ί / 🌳

Question#10 (reveal difficulty score)
A 59-year-old man develops fatigue and ...
Hemolysis πŸ” / πŸ“Ί / 🌳


Question#12 (reveal difficulty score)
A 46-year-old man has dyspnea, orthopnea, and ...
Mitral regurgitation πŸ” / πŸ“Ί / 🌳

Question#13 (reveal difficulty score)
A 45-year-old woman develops proteinuria and ...
Tubulointerstitial nephritis πŸ” / πŸ“Ί / 🌳


Question#15 (reveal difficulty score)
A 23-year-old woman, who was diagnosed with ...
Substance P πŸ” / πŸ“Ί / 🌳



Question#18 (reveal difficulty score)
An 18-year-old woman comes to the physician ...
50% πŸ” / πŸ“Ί / 🌳


Question#20 (reveal difficulty score)
A 67-year-old woman comes to the physician ...
Low sensitivity πŸ” / πŸ“Ί / 🌳






Question#26 (reveal difficulty score)
A 3-month-old boy is brought to the physician ...
Mannose 6-phosphate πŸ” / πŸ“Ί / 🌳

Question#27 (reveal difficulty score)
A 55-year-old man with type 2 diabetes ...
Pravastatin πŸ” / πŸ“Ί / 🌳

Question#28 (reveal difficulty score)
A 23-year-old woman who is 6 months pregnant ...
Antiplatelet antibodies πŸ” / πŸ“Ί / 🌳



Question#31 (reveal difficulty score)
A 62-year-old woman comes to the physician ...
Ξ²-Tubulin πŸ” / πŸ“Ί / 🌳

Question#32 (reveal difficulty score)
A 54-year-old woman with terminal metastatic ...
Nonmaleficence πŸ” / πŸ“Ί / 🌳




Question#36 (reveal difficulty score)
A 4-year-old boy has had fever, abdominal ...
Shigella sonnei πŸ” / πŸ“Ί / 🌳

Question#37 (reveal difficulty score)
A 62-year-old man with alcohol-induced liver ...
Spironolactone πŸ” / πŸ“Ί / 🌳

Question#38 (reveal difficulty score)
A 23-year-old man with a 3-year history of ...
Psychogenic polydipsia πŸ” / πŸ“Ί / 🌳



Question#41 (reveal difficulty score)
A 2-year-old child undergoes resection of the ...
Increase in glomerular size πŸ” / πŸ“Ί / 🌳

Question#42 (reveal difficulty score)
A 13-year-old girl has an episode of severe ...
Epstein-Barr virus genome πŸ” / πŸ“Ί / 🌳

Question#43 (reveal difficulty score)
A 71-year-old man comes to the physician ...
Cilostazol πŸ” / πŸ“Ί / 🌳


Question#45 (reveal difficulty score)
A 39-year-old man reports bright red spots on ...
Constipation πŸ” / πŸ“Ί / 🌳


Question#47 (reveal difficulty score)
A 60-year-old woman has prolonged apnea ...
Succinylcholine πŸ” / πŸ“Ί / 🌳

Question#48 (reveal difficulty score)
A 48-year-old woman comes to the physician ...
Hypothyroidism πŸ” / πŸ“Ί / 🌳

Question#49 (reveal difficulty score)
A 92-year-old woman who was recently admitted ...
Atrophy of dermal collagen πŸ” / πŸ“Ί / 🌳



Question#2 (reveal difficulty score)
A study is conducted to identify healthy ...
Liver πŸ” / πŸ“Ί / 🌳

Question#3 (reveal difficulty score)
A 23-year-old woman comes to the physician ...
Collagen synthesis πŸ” / πŸ“Ί / 🌳

Question#4 (reveal difficulty score)
A 20-year-old man comes to the physician ...
Olfactory πŸ” / πŸ“Ί / 🌳


Question#6 (reveal difficulty score)
A 51-year-old man develops diaphoresis, ...
Alcohol withdrawal πŸ” / πŸ“Ί / 🌳

Question#7 (reveal difficulty score)
A 33-year-old woman with HIV infection is ...
Non-Hodgkin lymphoma πŸ” / πŸ“Ί / 🌳

Question#8 (reveal difficulty score)
A 58-year-old man is brought to the emergency ...
Hypertension πŸ” / πŸ“Ί / 🌳


Question#10 (reveal difficulty score)
A 65-year-old woman who has a 25-year history ...
Hydroxylation of proline πŸ” / πŸ“Ί / 🌳

Question#11 (reveal difficulty score)
A 37-year-old man who is HIV positive comes ...
Nortriptyline πŸ” / πŸ“Ί / 🌳


Question#13 (reveal difficulty score)
A 62-year-old woman comes to the physician ...
Bronchogenic carcinoma πŸ” / πŸ“Ί / 🌳




Question#17 (reveal difficulty score)
A previously healthy 55-year-old man has ...
Renal artery stenosis πŸ” / πŸ“Ί / 🌳

Question#18 (reveal difficulty score)
A 35-year-old man comes to the physician ...
Gastrin πŸ” / πŸ“Ί / 🌳


Question#20 (reveal difficulty score)
A 5-year-old boy is brought to the physician ...
Hypophosphatemia πŸ” / πŸ“Ί / 🌳

Question#21 (reveal difficulty score)
A 47-year-old woman comes to the physician ...
Contact with parakeets πŸ” / πŸ“Ί / 🌳





Question#26 (reveal difficulty score)
A 33-year-old man comes to the physician ...
Rectus femoris πŸ” / πŸ“Ί / 🌳

Question#27 (reveal difficulty score)
An investigator is studying patients with ...
Case series πŸ” / πŸ“Ί / 🌳


Question#29 (reveal difficulty score)
A 15-year-old girl is brought to the ...
Doxycycline πŸ” / πŸ“Ί / 🌳


Question#31 (reveal difficulty score)
A 48-year-old man is brought to the emergency ...
Cl-: 96 mEq/L; HCO3-: 8 mEq/L πŸ” / πŸ“Ί / 🌳


Question#33 (reveal difficulty score)
A 65-year-old woman with cardiovascular ...
Increased bile salt πŸ” / πŸ“Ί / 🌳


Question#35 (reveal difficulty score)
A 62-year-old man comes to the physician for ...
Contemplation πŸ” / πŸ“Ί / 🌳


Question#37 (reveal difficulty score)
A 16-year-old girl with cystic fibrosis is ...
Vitamin E πŸ” / πŸ“Ί / 🌳

Question#38 (reveal difficulty score)
A 45-year-old man comes to the physician ...
Tumor necrosis factor πŸ” / πŸ“Ί / 🌳

Question#39 (reveal difficulty score)
A 30-year-old woman develops serum sickness ...
C3a πŸ” / πŸ“Ί / 🌳


Question#41 (reveal difficulty score)
A 56-year-old man with a 20-year history of ...
Naloxone πŸ” / πŸ“Ί / 🌳

Question#42 (reveal difficulty score)
A 65-year-old woman dies 6 months after the ...
Meningeal πŸ” / πŸ“Ί / 🌳


Question#44 (reveal difficulty score)
A 45-year-old man comes to the office for ...
Starchy foods πŸ” / πŸ“Ί / 🌳


Question#46 (reveal difficulty score)
A 28-year-old woman at 32 weeks' gestation ...
Obstructive uropathy πŸ” / πŸ“Ί / 🌳


Question#48 (reveal difficulty score)
A 24-year-old man comes to the emergency ...
Lipoprotein lipase πŸ” / πŸ“Ί / 🌳



Recent comments ...

... amorah made a comment on nbme20/block3/q#35 (A 51-year-old man has the acute onset of fever and...)
 +40 
submitted by amorah(105)
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eeFrv &g;-t rleu tou lfet uicetrlnrav ufalier XTSMP-M harxlispypo -&t;g rleu tou sunPoecmsity dicnyeiorivj Ke atlprntans btu no W/RBCBC in erniu ;g-&t uerl tuo stalpnartn noceteirj

avnieLg VCM dan aplticay oacrcibmuetmy as teh rigmeanin two i.stopon CMV is mero kyleli ni a tapnntlras .etpaitn

... hayayah made a comment on nbme20/block1/q#40 (Monoclonality of neoplastic cells in endometrial...)
 +35 
submitted by hayayah(1170)
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soplaieaN is wne iusest rwohtg hatt si eeagu,ntldur er,resbrelivi adn lnomnoac.lo

aolCniylt can be ndemeeitrd by sactehp-6peslg-uooh daheseyeongrd )(DP6G mneeyz mrsoosfi. PG6D si endlX-ki.

*Fro oerm fnniooatimr chcke uto Ch. 3 peNaliosa ni moPatah

hello  This is great, thank you. +5
breis  Pathoma ch. 3 pg 23 "Basic Principles" +9
charcot_bouchard  Shoutout to Imam Satter! Without him this question wasnt possible for me to answer in 10 sec. +16
fatboyslim  Clonality can also be determined by androgen receptor isoforms, which is also present on the X chromosome (Pathoma Ch. 3 Neoplasia) +2
lovebug  @fatboyslim thanks for reminding! +1
makingstrides  Just to make sure I got this right, because this is neoplastic and its monoclonal, you want to look at the isozymes to determine its clonality? +2
... hayayah made a comment on nbme20/block3/q#44 (A 56-year-old man is brought to the emergency...)
 +35 
submitted by hayayah(1170)
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VL sepotdp knwgroi, reuespsr aebckd pu toin pulm c.uricit lmuP rtciiuc ulyorgh si maed fo 3 pstra"" - het a,rcseipllai atsineltriit ,caesp nad eht olai.evl

nI cgrniceodia oshc,k the taexr dlobo asrscenie lalpciary ithcadoytsr usrrpsee, rnviigd fduli tino het tsliiitenrta .pcaes Cmporead to eth eoli,vla the rnstiittleai espac won hsa emor udifl s(uht erom ittnsirileta rocshtyaidt rpursees dna sels oinccot espersur deu to aotir of ulfdi ot i,ntp)ero nda sa a esrltu of tish nuclniaabng of rofs,ce idlfu svoem iont hte laiovel &;g-t- arpyulnmo da.eme

... masonkingcobra made a comment on nbme20/block4/q#21 (A 47-year-old woman comes to the physician because...)
 +33 
submitted by masonkingcobra(384)
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egPa 2 has a agret pteruic

S.it(g)6cterr1a/pit-n7a6-/wh8w:ni9o/6sj14l0w/.p3efo0190c2/dl

kamilia20  chlamydophila psittaci?? +1
... hayayah made a comment on nbme20/block2/q#32 (A 12-year-old girl is brought to the physician by...)
 +30 
submitted by hayayah(1170)
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A gbi intgh erhe too is iincngto that teh PLA si .erseadcde Olsattebos iivattcy is remsadeu yb bneo .PAL I kniht htat aws eht nami ufcso rhee nad tno atth yuo sriecenylsa ndee ot nkow eht 1FABC eeng mtaoiu.nt

sympathetikey  Exactly. That's the only way I got to the answer. +4
pakimd  isnt increased alk phos consistent with increased osteoblastic activity? +
champagnesupernova3  A defect with chondrocytes would cause an short limbs like in achondroplasia so those are ruled out +1
pg32  Exactly. Can also be helpful if you remember that the clavicles are formed by intramembranous ossification rather than endochondral; that allows you to rule out the chondroblast/cyte answer choices. +7
... medbitch94 made a comment on nbme20/block3/q#26 (A 3-month-old boy is brought to the physician...)
 +30 
submitted by medbitch94(50)
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9F0A12 agep 4:7 lcIl-e isdaese (inicuolns llce liipieuodsssoais/medc ptey tieβ€”nr)IdIhie losyolams grtaoes d;edsrrio eetcfd in gyoeiaorlcpasheNautpsfa1-nmclrot-lsnhys-e ;r&arr euarfli fo eht Ggoli ot oplahtrhoepys nseoman essrudei grin(omf st)oah6nan-os-pphmee no ecoyirtpongsl ar&rr; rnseoitp rea etecdesr erlrlcalxyuelta rahter ahtn ideelvdre to ss.eslmooy slstRue in esorca ifaacl fu,tsraee vlinigag ,lpyhrsapeai uoecdld ,ecrnaso tiecdrtser ntjio me,smnoetv claw danh edotismfre,i soool,ikipycssh nda ighh plmaas vsleel of alsyomols zyn.emse etOnf laatf ni dcdo.hilho

athenathefirst  FA page 47 +
... hello made a comment on nbme20/block3/q#44 (A 56-year-old man is brought to the emergency...)
 +29 
submitted by hello(397)
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Pt'tsiean pysmmsto angeb 30 inm fetra mgwoin lnaw (..ei retfa ndogi asclihyp vyi)tit.ca eH sah eserev scthe pian nad si ,colo ,ylacmm crh.epdioiat He ahs dicnrease muolrapny rytaer psrserue adn nreescaid etlf iralta rsseu.epr anTek arttoe,ehlg ihts si oaicrgnidce ckso.h

cnerigadioC kocsh si a htera umpp lpmerob -- het LV s'tni kor.iwgn

hneW het L,V nits' rkoinw,g ti esasuc a cbka up ni teh inoitcder ispoepot ot who odbol rlymlano os.wfl Throeer,ef lobdo ilwl acbk pu in the .sguln

hiTs escasu earcnside iaprlcaly athoycrtdsi prssruee g-;t&- itsh edisrv more ldufi onti het utietmstrini t&-;-g hist sescau cdisrnaee slanteiriitt tdaohiytscr surrpees t&--;g erhte is won orme uidfl hatn rnmloa ni the niuteimttris -t-;g& isth tfefsac hte nieoprt otair tihniw het nsuitritetm -t&-;g shit cesaus cdedesear iintlerattis coconit eessprru.

targetusmle  awesomely explained :) +
lilyo  This was amazingly explained Thank you @Hello! +
pseudopseudopth  For edema to occur shouldn't interstitial oncotic pressure be increased?(when proteins are there, they can pull the fluid) +1
pseudopseudopth  And when increased interstitial hydrostatic pressure is pressure, shouldn't it oppose the edema by pushing against it? +1
pseudopseudopth  *when interstitial hydrostatic pressure is increased +2
pmofmalasia  You don't necessarily need to have increased oncotic pressure, you're correct in that decreased oncotic pressure would act against causing edema but as long as the net change in forces still acts "for" edema it will still occur. For example in this scenario, if the capillary hydrostatic pressure is greater than the change in interstitial hydrostatic and oncotic pressures. Also, the change in interstital hydrostatic and oncotic pressures is a direct result of the edema in this scenario, so it's more like they're responsible for setting the new equilibrium - if they didn't counteract it, you'd never come to a point where the leakage of fluid stops. +
kcyanide101  Hey guys please help me affirm.... so based off your explanation, if it were hypovolemic chock.... capillary Hydrostatic pressure will drop, due to blood loss... interstitial hydrostatic Pressure will drop as fluid will move into the capillaries to balance things out and interstitial oncotic pressure will increase due to fluid loss from the interstitium.... IS THIS CORRECT? tnx +
... imgdoc made a comment on nbme20/block4/q#20 (A 5-year-old boy is brought to the physician for a...)
 +28 
submitted by imgdoc(161)
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uYo acn srcso otu eth tpo teher ranwse icsheo,c B,.,CA uYo ownt eb bnrairsobge gyihannt in the CTP ni ois'nfnca ydsor.nme kngoioL at aik,ploheaym hnpioyaarmte, dna shmaohytiahpppeo nw.o pkaoyieHalm ca'tn eb etcrocr ubsecae enev ughoht uaomtpssi is lsot ti will be errboeadsb ta the talre chtki nedscangi lopo nad if tath esdton kmae nese,s teh boyd illw tjduas rfo olw sruem ssiomutap utb gtnvactiai teh K+/+H pmpu on slcl.e tI sn'ti poiahntyaerm esauebc at het glleiontcc dtcu rclnaippi e,llsc pooribaetrns ilwl .corcu sTih elseva mophihapaeyopsht as the corterc nad lony rnsewa co.eihc

imgdoc  by* +2
larascon  Excellent explanation, thank you ! +2
waterloo  It's worth mentioning, that 25% of Na is reabs in the thicc ascending limb. 67% of filtered Na is reabsorbed in the PCT, whereas 85% of phosphate reabsorbed in the PCT. So pt more likely to show Hypophos. +3
coconut  UWorld QID:7626 says lab results in people with Fanconi syndrome will show hypokalemia +
j44n  coconut i thought that too but then i remebred fanconi is associated with hypophosphatemic rickets/ VIT D resistant rickets and this little dude is going to be growing because he's 5 and thats gonna increase the demand for phosphate in his body +
... celeste made a comment on nbme20/block2/q#6 (An 18-year-old boy has just been diagnosed with...)
 +27 
submitted by celeste(88)
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lieWh the itelifem srki in hte ergnlea noipalpuot is ujts bwleo %,1 ti is 5.6% in igtreesfer-d avsrietle fo paeisntt nad ti isser to more tnah %40 ni niooygoczmt tnwsi of aecfdfet eplo.ep azignynlA aisslcc estuisd fo eht snctegei fo hpnierozshaci odne as yelra sa in 0193s, ehrFsci cdcluoens that a eodoacncncr trea orf hicossysp fo btoua %50 in tooymncizog nsiwt sseem to be a tiirlcase s,meettia hhcwi is inicanyisfglt ihehrg hnta atth ni yizcgitdo siwtn fo aobtu 0–191% (e/C#63r.9gmtcM/veal/6.pi3nofmih.cr4snci/b52lPn)

imnotarobotbut  How is one supposed to know this before having read this article? +36
imgdoc  This question falls under the either you know it or you dont category. It isnt in FA or Uworld +2
jaxx  So why would these A-holes put it on there as if prepping for this exam isn't stressful enough :-| +9
doodimoodi  Lol just why seriously +3
champagnesupernova3  This was mentioned in the Kaplan behavioral videos +
usmlecrasher  and there's so much unnecessarily BS instead of real questions +3
j44n  I'm just glad we're seeing this garbage now instead of having an aneurysm in the prometric center +7
feanor  This Question is a perfect example of where you just jump off your seat to demand a refund or you decide to go Antisocial Disorder on your computer screen. +
olddoc  I don't think it has to do with any extra info. The dx is FAP (mutation in APC gene) which is inherited in an AUTOSOMAL DOMINANT fashion ("A" is the mutant allele and "a" is the normal one. The girl in the question stem MUST be heterozygote "Aa", getting the mutant "A" from her sick father and "a" from her healthy mother. Assuming she marries a healthy husband (aa) (this is a normal assumption in genetics questions), their kid will be Aa (the phenotype that will 100% result in CRC) by a probability of 50%. Recall that FAP will 100% progress to CRC is not prophylactically removed. +3
olddoc  FA 2019 Page 381 +
conniea168  It sucks because in psychiatry rotation as MS3 you may come across this fact that rate is ~50% in identical twins, but other than that it's unfair for Step 1 :/ +
... hayayah made a comment on nbme20/block1/q#34 (A strain of Escherichia coli produces a...)
 +26 
submitted by hayayah(1170)
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Meseinss uittaonms evlivno a ecinoltdue tbiuotiustns tnlguersi ni aghcned miaon da.ics eStsmeimo hte ctfsfee of seessinm iatnutmos mya be ylno aartnppe udren tcarine nminoavnletre ;nioistndoc husc enssisem ouamttins are eldalc diotolaninc tusin.aotm nyaM eissmsne iumotasnt tulser ni opsnietr ttha aer tlsil ann,tlficou ta aelts to emos ereegd.

A,slo all eth orthe nseraws oudwl yblbarop lveea ouy with tiehre a yragtel atelder ro ntolac-ufnoinn .irtopne

thefoggymist  I chose nonsense because I thought it'll make the enzyme shorter (since less bonds = more heat liable = can't work at 42 degrees) but yea, probably won't work even at 30 if it's an early nonsense. +11
joanmadd  A good clinically related example is HbC disease on electrophoresis. HbC disease is due to a missense mutation (glutamic acid (-) for valine (neutral)). The mutated hemoglobin is still fairly functional but when placed on gel electrophoresis the HbC migrates the least far from the negative electrode due to less negative propulsion (lack of wild type glutamic acid). +3
fatboyslim  @Joanmadd Just to clarify, glutamic acid substitution for valine occurs in sickle cell disease not HbC. HbC is glutamic acid substitution for lysine :) +8
rockodude  lyCCCCine for HbC +3
l0ud_minority  I was thinking this was r/t a transposon inserting itself in DNA. +
... strugglebus made a comment on nbme20/block1/q#17 (A 50-year-old woman comes to the physician because...)
 +25 
submitted by strugglebus(181)
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eehwoNr hvea I been ebal ot dnfi ywh eth elhl shti is a hnig.t

yotsubato  Its not in FA, Sketchy, or Pathoma, or U world. I knew it wasnt cancer because its bilateral. And Diabetes made no sense to me. So I just threw down Drug effect and walked away. +7
breis  same^^^ +
feliperamirez  The only possible explanation I think is that she was under a K sparing diuretic, such as spironolactone (which would lead to gynecomastia). +
chandlerbas  you had me at its not in sketchy ;) +3
j44n  i thought HTN induced empty sella would cause this because they got type II diabeetus. So if you need a pro zebra hunter holler at me. +
... andrewk1 made a comment on nbme20/block2/q#9 (An otherwise healthy 16-year-old girl comes to the...)
 +25 
submitted by andrewk1(25)
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Tish rlgi ahs resiecxe eucnidd tmhsa.a It si ont wlel surnedodto yhw ti henpasp btu het esrriggt rae ezodceni.rg allymNro newh batrgehni crocus ari si tenak ni yb the onse nda eht asaln speassga adn uneibsttra act ot vmoeer dstu dan iumwmrdyfa/hi het i.ar Lacogylil stih kemsa eht ria edresn T=RPn.v oS wneh inei,grcexs atebnihgr hhuorgt the osen si eadresced adn adlpceer yb reom giuovosr tomhu iten.gahbr Tshi amesn eht ira si not ddfmueiiih dan rmewda .pu ehT iar is ssel ensed nad eht hmatsa ess.une Teh sneqoiut toko shti meas cpilpneir xtceep dvereers ti by siakgn waht ltaeexrn nicdonoit ludoc aedl ot hte atamhs dan htat owldu eb clod dyr ri.a

eacv  oooh thank u !!! I choose wrong, cold air hehhe +6
eacv  moisture air instead! +


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