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Retired NBME 20 Answers

nbme20/Block 1/Question#11 (reveal difficulty score)
The sequence surrounding the first two exons ...
Disruption of normal splicing by creation of a new 3′ splice site 🔍 / 📺 / 🌳 / 📖
tags: biochem dna repeat

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 +20  upvote downvote
submitted by drdoom(1206)
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sA dceidebrs ni hte sntuoqie tm,se ihst ntuatmoi ccusor itwihn an iontnr a( nege getsmen cwhih si iestbanrdcr RtA&;]-g[NNAD tub tno t)as.nteldra NRA slgipnci zme)ynse( gabr RNA nad olp“o ”;ti an tnnoir is tuc otu nad teh xnseo on terihe side of het nrotni rae i,addejno ekil :htis

nn—onx1—2xnoeeorti ;g=&t —xooe2nx1ne

,yclpailTy thsi sclgipni urcsco ta teh yerv deesg of hte irnnto (ahwt I edteodn tiwh the ”—“ )crc.aetarh tuB in our aces, a mnutoita niithw hte otnrin is suincag NAR niscligp neyzme to ngeoizcre a nwe t:sei het lecpisr cust wtiihn eht rointn dn(atsie fo ta het ryev de,eg as it ho)uds.l ,oS we tge heonismtg ahtt sokol eikl is:ht

nto2rxie—noex1—n

h’saTt a oatllyt tnfedrife AmNR uco,meell dan t'si igong to mkae ruo bgoiβn-l rnitoep okol dan( h)beeav llufway tsnrg.ea

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drdanielr  I eemrbemr ttha ni hte ANrRm,-pe the isgipnlc istes fo eht nrtnio rhwee eth lmceeoissop ttehcasa era nrrueodusd by -AUG"-G"- ikle c"ag",u os here eth sumhoooogl ADN to ihst strdna udolw eb rrdnabtcies ntoi a..g.u........"...g...." adn itsh uwlod ectear a 3' icsle etis oot nsoo +7
vivarin  if itsh si pessuopd to eb AeR-rN,mp hyw aer heter 'Ts ni eth cns?qeeeu 'Im os defnscuo yb stih rof emos earson +8
sars  hsiT si eht gene (N,DA) ont eoogneturesh RANm. +
athenathefirst  eTh gsigbte ecul htye dsia shit si B smliahest,aa chhwi nvee fi yuo t'dnid wokn yiaghntn auobt sxneo dan rnsoint uoy doluhs vhae nokwn ahtt b aiamatsehls veoisvnl a oanmittu in inclpigs ro omterorp etis apmho(ta epga 4.)4 I got hist iotnesqu rngwo oto :( +1

Translocation may result in failure to transcribe RNA because of disruption of a regulatory element (eg, promoter) within a gene.

The affected gene will not be expressed or will be expressed in a dysregulated manner compared to the normal phenotype



 +5  upvote downvote
submitted by monoloco(155)
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shiT sah to do itwh tnrnio .ngscpiil ereRmbem A.TGG ishT muoatitn diuedcn na AG olcsre ehewr it asw epsposdu to ,eb so mose of ttha trionn stju beacem na .noex

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 +4  upvote downvote
submitted by waterloo(126)
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I tepreriedtn "seuqeecn rgnnsriduou sfrit otw nxose of n"gee - to mean ehyt must be kingalt utboa stornin. eerhT fo hte awsenr eoicchs ntod' evha hcmu to od htiw rniots.n

  • nssiesem tnitaumo dlouw heva ot be in teh onex to sucae heancg ni omnai c.dia
  • aaloyyodtpeinnl is ta the dne fo hte mRAN
  • tnboiihnii fo eoinciratlp is AND

that may tno eb iar tgiht, btu sehpl wnaror .ndow Asol kiownng eoms Bahmisesl-ata si due ot rvnasati in omraalbn sinciglp elh.ps A(F 0921 gp 43)

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 +1  upvote downvote
submitted by s1khwitit(1)
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sloa mreemerb ttha s-liatBaaemsh is due to pntio nastumoit ni csepli tises adn oeromprt sueneqcse A1(F9 )10.g4p If oyu ceeatr a inaoutmt in a lpsice esti uoy lwli ulersy ssem pu the otccerr mRAN eddeen to kame a ntuafcionl Bnlib-go peroit.n tTha is who I awrensde het uton.eqsi

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