NBME 22 Lung cancer (NBME Answers)

NBME 22 Answers

nbme22/Block 1/Question#31 (reveal difficulty score)
A 60-year-old woman comes to the physician ...
Lung cancer 🔍 / 📺 / 🌳
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+14
submitted by ∗famylife(102),

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+5
submitted by ∗atstillisafraud(214),

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Weitgh loss - kinht rincr ncaymHaeotape - SIDHA frmo smlla clel unlg ncd aceraEme + JDV - VSC ymdsonre

peridot I was thinking lung cancer secreting SIADH, resulting in hyponatremia. But because the question asked specifically about the cause of the facial edema, I put hyponatremia (answer choice C). I was wondering how you guys were able to differentiate between C. hyponatremia and E. lung cancer? Thank you! +2

mannan The first thing that crossed my mind was SVC syndrome from the cancer obstructing the R brachiocephalic vein preventing venous blood from returning to the heart (and staying in the facial area). Also I assume Hyponatremia would be equivalent to decreased body volume so there wouldn't be edema. FA Renal physiology section has a good chart on what happens during electrolyte imbalances (hypo and hyper) +2

mannan @peridot +2

peridot I was thinking that hyponatremia would be more loss of osmotic pressure --> edema, but I definitely see the argument for a mass that's simply blocking blood flow. Thank you! +1

jaramaiha only thing affecting osmotic pressure is albumin, which would be more towards liver cirrhosis. The body will attempt to maintain a Na+ of 140 with various mechanisms, but doesn't contribute to osmotic pressure. +1

+5
submitted by ∗thirdaid(10),

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makinallkindzofgainz I agree! Superior sulcus tumors is a lung carcinoma that occurs in the apex of the lung and can cause SVC syndrome. +2

+0
submitted by ∗agraham416(3),

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