Couldn't the answer also be IL-2? Why can't you use cyclosporine in this patient with RA?
androFirst thing to note is that methotrexate has been shown to have the most activity of the non biological DMARDS in reducing erosions in RA . It is typically used in combination with another DMARD . Our Patient is not responding to our best Therapy for erosive RA ---- This is refractory RA .
The algorithm generally used in Tx of R.A is that if non biological DMARDS have failed , as in our Pts , Biological therapy is initiated eg - Monoclonal antibodies against TNF alpha ( adalimumab ) or decoy receptors to TNF alpha ( etarnecept )+4
submitted by โbingcentipede(356)
This is a patient with RA not responding to steroids or MTX. Next line of therapy is a TNF-a inhibitor like adalimumab, an anti-TNF alpha antibody.