Vancomycin binds to the terminal d-Ala, d-Ala of the peptide side chain of Peptidoglycan which is normally used to cross-link Peptidoglycan strands together. Since the d-Ala, d-Ala is not available to be crosslinked when it is bound by Vancomycin, the Peptidoglycan wall cannot be crosslinked properly, thus compromising its structural rigidity. Bacteria which switch the terminal d-Ala for a d-Lac are resistant to Vancomycin. Helpful Diagram on Wiki
chaosawaitsBut isn't impaired influx/increased efflux also a common method of resistance for Vancomycin? So how do you know the answer is not also "upregulation of rapid efflux pump"?+
submitted by โfruitkebabs(33)
Vancomycin binds to the terminal d-Ala, d-Ala of the peptide side chain of Peptidoglycan which is normally used to cross-link Peptidoglycan strands together. Since the d-Ala, d-Ala is not available to be crosslinked when it is bound by Vancomycin, the Peptidoglycan wall cannot be crosslinked properly, thus compromising its structural rigidity. Bacteria which switch the terminal d-Ala for a d-Lac are resistant to Vancomycin. Helpful Diagram on Wiki
FA2020, p190