geekymlethank you! it was the wording of the question which got me!!+1
androI think there were two possible ways of approaching this.
The first was by appreciating that the tumor cells ( which release Growth Hormone ) would express growth hormone releasing hormone receptors GHRH receptors - GHRH uses the Gs signalling pathway ( Net effect an increase in cAMP from the increased activity of adenyl cyclase )
The second and more straight forward approach
From the stem of the question already they told us we are dealing with an overactivation of the G alpha stimulatory subunit .
If the GTPase aint working ( meaning it cant be inactivated ) , the effect would be an increase in the activity of adenyl cyclase+5
meryen13well I know you guys probably thought its a jam kinase because of somatotroph adenoma. we know growth hormone has a jar/ kinase right? but the question was really sneaky and mentioned that there is a G alpha s subunits protein!! that should remind you that Gs activates adenylyl cyclase to increase CAMP. the key world was Gs (and I didn't think about it cause I just saw somatotropin adenoma)+3
m0niaguiwhere in FA2020 will I find reference to this? I'm still at a loss ;/+1
kardm0niagui, Just Get this GHRH (Gs)cAMP ---->GH(Jak/STAT), And you can check all of them on the "Signaling Pathways of Endocrine Hormones"+3
submitted by geekymle(11)
i tried but i'm not able to reason this question. can anyone please help me on this?