dentistis getting this question correct contingent upon memorizing that fur is a transcription factor? +
pakimd@utap2001 can you explain how you figured that fur is a repressor and not a promoter?+
pakimdoh i just clicked on the link you posted. sorry+
utap2001It doesn't matter if Fur is suppressor or promoter. The question stem says " Ferric uptake regulation protein (Fur) binds tightly to DNA a short distance from the 5’end of the genes for these virulence factors." So it's function to modulate the transcription of DNA. +4
drdoom@dentist, utap2001 hits the key sentence of the stem. No one has ever heard of Fur, but the description of a protein that binds tightly to DNA, and does so nearby the start of a gene (5'), is unlikely to be anything other than a transcription factor.+
drdoom(Transcription of DNA is such a highly conserved and tightly regulated process that no protein other than a TF can willy-nilly bind to DNA in the manner described in the stem.)+
blue4415@ pakimd Because the more Fur binding，iron in the “media “ increases its concentration; -last sentence
And it’s name is “ferric uptake “ regulator protein (which regulate the mRNA transcription ), you can imagine the mRNA product is a ferric uptake transport or like DMT-1 in human intestinal .
All above , it’s like a repressor , which is a transcription factor +
submitted by ∗utap2001(27)
Fur is a TRANSCRIPTION FACTOR that acts as a REPRESSOR to control the gene expression.
if INCREASE IRON CONCENTRATION--> INCREASE Fur DNA binding = INCREASE the REPRESSOR function and the opposite action w/ [LOW IRON].
Fur helps in the BACTERIAL VIRULENCE FACTORS control.
https://en.wikipedia.org/wiki/Ferric_uptake_regulator_family