The ductus arteriosus is kept patent by prostaglandins (which is why the baby is started on a prostaglandin drip id we need to keep the ductus patent in some hypoxic congenital heart diseases).
Thus, to close the PDA, prostaglandins are decreased. cyclooxygenase inhibition (COX) is one way of decreasing prostaglandins and is the physiologic way of closing the ductus as well as how we close it if necessary (to close a PDA you give a baby NSAIDs, FA2020 p486).
submitted by โcassdawg(1780)
The ductus arteriosus is kept patent by prostaglandins (which is why the baby is started on a prostaglandin drip id we need to keep the ductus patent in some hypoxic congenital heart diseases).
Thus, to close the PDA, prostaglandins are decreased. cyclooxygenase inhibition (COX) is one way of decreasing prostaglandins and is the physiologic way of closing the ductus as well as how we close it if necessary (to close a PDA you give a baby NSAIDs, FA2020 p486).