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NBME Step 2 CK Form 8 Answers

step2ck_form8/Block 1/Question#41 (reveal difficulty score)
A 42-year-old woman comes to the physician ...
Nonalcoholic steatohepatitis ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags: GI HPB DDX

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submitted by โˆ—step_prep(148)
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  • Young obese woman with no alcohol history found to have dyslipidemia and mildly elevated LFTs most consistent with non-alcoholic steatohepatitis
  • Patients use of acetaminophen not sufficient to cause liver damage (more commonly leads to fulminant liver failure in patient with overdose), does not have other signs of hemochromatosis (bronze diabetes, cardiomyopathy, etc.), LFTs incompatible with primary biliary cirrhosis (would be cholestatic with direct hyperbilirubinemia and alk phos >> ALT/AST, and no signs of hepatitis on labs (negative HCV antibody and negative HB surface antigen)
  • Key idea: NASH has overtaken alcoholic steatohepatitis as most common cause of chronic liver disease and cirrhosis in certain countries

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