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NBME Step 2 CK Form 6 Answers

step2ck_form6/Block 4/Question#33 (reveal difficulty score)
A 30-year-old woman comes to the physician ...
Serum thyroid-stimulating hormone concentration ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags: pharm endo

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submitted by โˆ—yb_26(315)
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lithium can cause hypothyroidism by interfering with normal synthesis and release oh thyroid hormone

  • treat with levothyroxine, no need to discontinue lithium
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submitted by โˆ—carolebaskin(109)
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At baseline:

  • measure Cr, Ca, UA, BUN, thyroid function

Then,

  • monitor TSH q6-12m and supplement with T4 rather than discontinue lithium
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submitted by โˆ—step_prep7(71)
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  • Patient with bipolar disorder who was started on lithium and has experienced weight gain most consistent with a picture of lithium-induced hypothyroidism
  • Key idea: Patients on lithium should have regular TSH monitoring every 6-12 months regardless of symptoms
  • Key idea: Lithium is associated with hypothyroidism, nephrogenic diabetes insipidus, chronic kidney disease and hyperparathyroidism
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submitted by โˆ—drmohandes(193)
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I did not understand why you don't check renal function.

Doesn't lithium affect both thyroid and kidney? Also, she has no clinical signs of hypothyroidism, so I figured we need to check her renal function.

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sassy_vulpix  She has weight gain & sleep disturbances (? not sure if this is current or before medication) +2
drmohandes  True, that information could point at hypoT. +1



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