Lack of CD18 (LFA-1 integrin) on phagocytes is the cause of leukocyte adhesion deficiency type 1 (LAD1). Since phagocytes like neutrophils and macrophages can't get out of the bloodstream, they are stuck in the blood, hence the leukocytosis with WBC count > 10,000. Since the leukocytes are stuck in the blood, they can't mount an effective immune response against bacteria.
fatboyslimAlso to add, they have recurrent BACTERIAL infections but not viral infections because neutrophils don't play a vital role in fighting viral infections, lymphocytes do.+
namesthegame22Delayed separation of the umbilical cord is common. +
submitted by โneonem(629)
Lack of CD18 (LFA-1 integrin) on phagocytes is the cause of leukocyte adhesion deficiency type 1 (LAD1). Since phagocytes like neutrophils and macrophages can't get out of the bloodstream, they are stuck in the blood, hence the leukocytosis with WBC count > 10,000. Since the leukocytes are stuck in the blood, they can't mount an effective immune response against bacteria.