Wegener granulomatosis, also called granulomatosis with polyangiitis, is a vasculitide that commonly presents with the triad of focal necrotizing vasculitis, necrotizing granulomas in the lung and upper airway, and necrotizing crescentic glomerulonephritis (FA2020 p 314 and 596)
Wegener is associated with chronic sinusitis, hemoptysis, and PR3-ANCA (antineutrophil cytoplasmic antibody, formerly called c-ANCA).
None of the other answers are associated with ANCA except Churg-strauss syndrome. Churg-strauss syndrome (also called eosinophilic guanulomatosis with polyangiitis) is associated with MPO-ANCA (formerly called p-ANCA). However, Churg-strauss does not have lower respiratory involvement, hemoptysis, or patchy lung opacities on CXR.
j44nAll ANCA's are against proteins in the cytoplasm, they were intentionally vague and wanted you to ddx this off of clinical pres+1
jurrutiaChurg-Strauss can affect the lungs, but not the upper airway. +2
shieldmaidenActually Churg-Strauss does affect the upper airway (sinusitis); you are confusing it with microscopic polyangiitis which is also associated with MPO-ANCA like CS and with lower airway involvement like Wegener. A way to tell these apart is that (1) CS includes asthma, granulomas, eosinophils, while (2) MPA has no granulomas and does not involve nasopharynx, and (3) W has granulomas in both upper and lower airways and involves PR3-ANCA instead.+1
submitted by โcassdawg(1780)
Wegener granulomatosis, also called granulomatosis with polyangiitis, is a vasculitide that commonly presents with the triad of focal necrotizing vasculitis, necrotizing granulomas in the lung and upper airway, and necrotizing crescentic glomerulonephritis (FA2020 p 314 and 596)
Wegener is associated with chronic sinusitis, hemoptysis, and PR3-ANCA (antineutrophil cytoplasmic antibody, formerly called c-ANCA).
None of the other answers are associated with ANCA except Churg-strauss syndrome. Churg-strauss syndrome (also called eosinophilic guanulomatosis with polyangiitis) is associated with MPO-ANCA (formerly called p-ANCA). However, Churg-strauss does not have lower respiratory involvement, hemoptysis, or patchy lung opacities on CXR.