FA 2020 ,pg 195 Metronidazole MECHANISM Forms toxic free radical metabolites in the bacterial cell that damage DNA. Bactericidal, antiprotozoal.
pg 251 Disulfiram-like reaction 1st-generation Sulfonylureas, Procarbazine,certain Cephalosporins, Griseofulvin, Metronidazole
acetaldehyde accumulates in disulfiram as acetaldehyde dehydrogenase is blocked
PG 353 Biguanides Metformin ADVERSE effect GI upset, lactic acidosis (use with caution in renal insufficiency) clue "sx began after drinking champagne -an alcohol"
pg 610 lisinopril adverse effects: Cough, Angioedema (both due to ย bradykinin; contraindicated in C1 esterase inhibitor deficiency), Teratogen (fetal renal malformations), increase Creatinine (dec. GFR), Hyperkalemia, and Hypotension. good thing HCTZ is not on the option pg 609 hydrochlorothiazide adverse effects: Hypokalemic metabolic alkalosis- can have nausea and vomiting, hyponatremia, hyperGlycemia, hyperLipidemia, hyperUricemia, hyperCalcemia. Sulfa allergy
FA page251 Disulfiram-like reaction. nausea vomiting
submitted by hemoglobin_(2)
FA 2020, pg 195. MTZ adverse effects -Disulfiram-like reaction (severe flushing, tachycardia, hypotension) with alcohol -headache -metallic taste