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Retired NBME Free 120 Answers
jean_young2019
Then why the choice D, “Inability of leukocytes to ingest microorganisms“, is incorrect？Moreover, Staphylococcus aureus is not an intracellular microorganism. Thank you for your help!
+1
houseppary
Because in CGD, the macrophages are capable of taking in bacteria but aren't able to do the oxidative burst required to actually kill them. So the macrophages just house live bacteria which leads to granulomas full of walled-off but not dead bacteria. And S. aureus isn't intracellular as part of its normal life cycle, but being eaten by a macrophage isn't part of its normal life cycle. Whether an organism gets eaten by a macrophage isn't part of the consideration of whether it's intracellular.
+7
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submitted by ∗bwdc(697)
Multiple infections. Abscesses. Then you hear decreased oxidative burst and immediately think NADPH oxidase deficiency aka Chronic granulomatous disease, which causes recurrent abscess-forming infections due to the inability to kill ingested organisms because of the inability to generate superoxide radicals.